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Compensatory neuroadaptation to binge drinking: human evidence for allostasis

dc.contributor.authorCorreas Marín, María De Los Ángeles
dc.contributor.authorCuesta Prieto, Pablo
dc.contributor.authorRosen, Burck Q.
dc.contributor.authorMaestu Unturbe, Fernando
dc.contributor.authorMarinkovic, Ksenija
dc.date.accessioned2025-01-20T14:56:16Z
dc.date.available2025-01-20T14:56:16Z
dc.date.issued2021
dc.descriptionThis work was supported by the National Institutes of Health, R01-AA016624, and the National Drug Plan, SPI/2010/051 (Spain)
dc.description.abstractAnimal studies have established that acute alcohol increases neural inhibition and that frequent intoxication episodes elicit neuroadaptive changes in the excitatory/inhibitory neurotransmission balance. To compensate for the depressant effects of alcohol, neural hyperexcitability develops in alcohol use disorder and is manifested through withdrawal symptoms. It is unclear, however, whether neuroadaptive changes can be observed in young, emerging adults at lower levels of consumption in the absence of withdrawal symptoms. Here, we used an anatomically constrained magnetoencephalography method to assess cortical excitability in two independent sets of experiments. We measured early visual activity (1) in social drinkers during alcohol intoxication versus placebo conditions and (2) in parallel cohorts of sober binge drinkers (BDs) and light drinkers (LDs). Acute alcohol intoxication attenuated early sensory activity in the visual cortex in social drinkers, confirming its inhibitory effects on neurotransmission. In contrast, sober BDs showed greater neural responsivity compared with a matched group of LDs. A positive correlation between alcohol consumption and neural activity in BDs is indicative of cortical hyperexcitability associated with hazardous drinking. Furthermore, neural responsivity was positively correlated with alcohol intake in social drinkers whose drinking did not reach binge levels. This study provides novel evidence of compensatory imbalance reflected in the downregulation of inhibitory and upregulation of excitatory signaling associated with binge drinking in young, emerging adults. By contrasting acute effects and a history of BD, these results support the mechanistic model of allostasis. Direct neural measures are sensitive to synaptic currents and could serve as biomarkers of neuroadaptation.
dc.description.departmentDepto. de Psicología Experimental, Procesos Cognitivos y Logopedia
dc.description.departmentDepto. de Radiología, Rehabilitación y Fisioterapia
dc.description.facultyFac. de Psicología
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.sponsorshipNational Institutes of Health (USA)
dc.description.sponsorshipPlan Nacional sobre Drogras
dc.description.statuspub
dc.identifier.citationCorreas, A., Cuesta, P., Rosen, B. Q., Maestu, F., & Marinkovic, K. (2021). Compensatory neuroadaptation to binge drinking: Human evidence for allostasis. Addiction Biology, 26(3), e12960. https://doi.org/10.1111/adb.12960
dc.identifier.doi10.1111/adb.12960
dc.identifier.officialurlhttps://doi.org/10.1111/adb.12960
dc.identifier.relatedurlhttps://pmc.ncbi.nlm.nih.gov/articles/PMC7930152/
dc.identifier.relatedurlhttps://onlinelibrary.wiley.com/doi/10.1111/adb.12960
dc.identifier.urihttps://hdl.handle.net/20.500.14352/115158
dc.issue.number3
dc.journal.titleAddiction Biology
dc.language.isoeng
dc.page.initiale12960
dc.publisherWiley
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.keywordGABA
dc.subject.keywordAlcohol
dc.subject.keywordAllostasis
dc.subject.keywordMagnetoencephalography
dc.subject.ucmCiencias Biomédicas
dc.subject.ucmPsicología (Psicología)
dc.subject.unesco61 Psicología
dc.titleCompensatory neuroadaptation to binge drinking: human evidence for allostasis
dc.typejournal article
dc.type.hasVersionAM
dc.volume.number26
dspace.entity.typePublication
relation.isAuthorOfPublicationc9116a6a-220e-474a-934e-e360bbf5d975
relation.isAuthorOfPublication7070623b-91a0-4590-86f6-227266503c1e
relation.isAuthorOfPublicationafa98131-b2fe-40fd-8f89-f3994d80ab72
relation.isAuthorOfPublication.latestForDiscoveryc9116a6a-220e-474a-934e-e360bbf5d975

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