Telomeres and telomerase in the clinical management of colorectal cancer

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dc.contributor.authorPiñol-Felis, C.
dc.contributor.authorViñas-Salas, J.
dc.contributor.authorValls-Bautista, C.
dc.contributor.authorFernández Marcelo, Tamara
dc.date.accessioned2025-12-05T09:26:45Z
dc.date.available2025-12-05T09:26:45Z
dc.date.issued2017
dc.description.abstractColorectal cancer (CRC) is the third most common cancer worldwide. Our aim is to describe the state of the art about the role of telomeres and telomerase in the clinical management of CRC and its potential utility as prognostic and diagnostic biomarkers and targets of new treatments. Telomere length could be a new diagnostic marker as an anomalous behavior is observed in peripheral blood cells when CRC patients and healthy people are compared. Moreover, telomeres and telomerase may be used as diagnostic markers considering that universal changes appear along the CRC process. Currently, new therapeutic cancer approaches are focused on inhibiting the maintenance of telomere length, choosing as targets telomerase -or its subunits- or the Shelterin complex. The goal of these therapies is the shortening of telomeres and the induction of cell senescence. Telomeres and telomerase emerge as useful molecular tools in the clinical management of CRC.
dc.description.departmentSección Deptal. de Bioquímica y Biología Molecular (Farmacia)
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.citationPiñol-Felis C, Fernández-Marcelo T, Viñas-Salas J, et al. Telomeres and telomerase in the clinical management of colorectal cancer. Clin Transl Oncol 2017;19:399–408. https://doi.org/10.1007/s12094-016-1559-0
dc.identifier.doi10.1007/s12094-016-1559-0
dc.identifier.issn1699-048X
dc.identifier.issn1699-3055
dc.identifier.officialurlhttps://doi.org/10.1007/s12094-016-1559-0
dc.identifier.urihttps://hdl.handle.net/20.500.14352/128503
dc.issue.number4
dc.journal.titleClinical and Translational Oncology
dc.language.isoeng
dc.page.final408
dc.page.initial399
dc.publisherSpringer
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu616-006.04-085
dc.subject.cdu615.4
dc.subject.keywordtelomeres
dc.subject.keywordtelomerase
dc.subject.keywordcolorectal cancer
dc.subject.ucmOncología
dc.subject.ucmTecnología farmaceútica
dc.subject.unesco32 Ciencias Médicas
dc.titleTelomeres and telomerase in the clinical management of colorectal cancer
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number19
dspace.entity.typePublication
relation.isAuthorOfPublicationf49e7a8a-62fc-43dc-83aa-1e48f60e1af6
relation.isAuthorOfPublication.latestForDiscoveryf49e7a8a-62fc-43dc-83aa-1e48f60e1af6

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