Impacto de un sistema inteligente para la mejora de los tratamientos antimicrobianos a nivel hospitalario
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2026
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29/10/2025
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Universidad Complutense de Madrid
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Abstract
La resistencia a los antimicrobianos (RAM) es una de las amenazas más graves para la salud global, responsable de 1,27 millones de muertes directas y 4,95 millones asociadas en 2019. Sin medidas eficaces, podría causar 10 millones de muertes anuales en 2050. Este aumento se debe principalmente al uso inadecuado o excesivo de antimicrobianos, favoreciendo la diseminación de microorganismos multirresistentes. Para abordar esta crisis, la Organización Mundial de la Salud (OMS) elaboró en 2015 un plan de acción global que promueve medidas como prevención de infecciones, control del uso de antimicrobianos en sanidad animal, desarrollo de nuevos fármacos, reducción del consumo innecesario e implementación de Programas de Optimización de Antimicrobianos (PROA). En este sentido, los PROA son esenciales para asegurar la adecuada indicación, selección, dosis y duración de los tratamientos, mejorar los resultados clínicos y minimizar las resistencias. De forma alineada, el Plan Nacional frente a la Resistencia a los Antibióticos (PRAN) y el enfoque “One Health” europeo fomentan su adopción coordinada...
Antimicrobial resistance (AMR) is one of the most serious threats to global health, responsible for 1.27 million direct deaths and 4.95 million associated deaths in 2019. Without effective measures, it could cause up to 10 million deaths annually by 2050. This increase is mainly due to the inappropriate or excessive use of antimicrobials, favouring the spread of multidrug-resistant microorganisms.To address this crisis, the World Health Organization (WHO) developed in 2015 a global action plan promoting measures such as infection prevention, control of antimicrobial use in animal health, development of new drugs, reduction of unnecessary consumption, and implementation of Antimicrobial Stewardship Programmes (ASP). ASPs are essential to ensure appropriate indication, selection, dose and duration of treatments, improve clinical outcomes, and minimise resistance. In line with this, the Spanish National Plan against Antibiotic Resistance (PRAN) and the European “One Health” approach foster coordinated adoption...
Antimicrobial resistance (AMR) is one of the most serious threats to global health, responsible for 1.27 million direct deaths and 4.95 million associated deaths in 2019. Without effective measures, it could cause up to 10 million deaths annually by 2050. This increase is mainly due to the inappropriate or excessive use of antimicrobials, favouring the spread of multidrug-resistant microorganisms.To address this crisis, the World Health Organization (WHO) developed in 2015 a global action plan promoting measures such as infection prevention, control of antimicrobial use in animal health, development of new drugs, reduction of unnecessary consumption, and implementation of Antimicrobial Stewardship Programmes (ASP). ASPs are essential to ensure appropriate indication, selection, dose and duration of treatments, improve clinical outcomes, and minimise resistance. In line with this, the Spanish National Plan against Antibiotic Resistance (PRAN) and the European “One Health” approach foster coordinated adoption...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Farmacia, leída el 29/10/2025













