Efecto neuroprotector de moléculas orgánicas y nanopartículas de selenio en la enfermedad de Alzheimer
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2023
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21/04/2023
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Universidad Complutense de Madrid
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Abstract
Las enfermedades neurodegenerativas se caracterizan por un progresivo deterioro en los aspectos cognitivos, como la memoria, el lenguaje, el comportamiento y la capacidad ejecutiva, siendo el envejecimiento el principal factor de riesgo. Suponen un gran reto parala sociedad, ya que son el primer motivo de discapacidad y la segunda causa de muerte a nivel global. Actualmente, afectan a más de 50 millones de personas en todo el mundo, con solo el 25% de los pacientes diagnosticados oficialmente, y estando previsto que alcancen los 152 millones de afectados para el año 2050. Por el momento no hay tratamientos efectivos para estos desórdenes neurológicos, con el consiguiente elevado coste socioeconómico que ello conlleva. Las cuatro enfermedades neurodegenerativas más frecuentes son la enfermedad de Alzheimer (AD), la enfermedad de Parkinson (PD), la esclerosis lateral amiotrófica (ALS) y la enfermedad de Huntington (HD). De entre ellas, la AD es la más prevalente, representando un 80% del total de los casos de demencia...
Neurodegenerative diseases are characterised by a progressive impairment incognitive aspects such as memory, language, behaviour, and executive capacity, with ageing being the main risk factor. They represent a major challenge for society since they are the leading cause of disability and the second leading cause of death globally. Currently, they affect more than 50 million people worldwide, with only 25% of patients officially diagnosed, and projected to reach 152 million by 2050. Now, there are no effective treatments for these neurological disorders, with the resulting high socio-economic costs. The four most widespread neurodegenerative diseases are Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and Huntington's disease(HD). Among these, AD is the most prevalent, representing 80% of the total number of dementia cases..
Neurodegenerative diseases are characterised by a progressive impairment incognitive aspects such as memory, language, behaviour, and executive capacity, with ageing being the main risk factor. They represent a major challenge for society since they are the leading cause of disability and the second leading cause of death globally. Currently, they affect more than 50 million people worldwide, with only 25% of patients officially diagnosed, and projected to reach 152 million by 2050. Now, there are no effective treatments for these neurological disorders, with the resulting high socio-economic costs. The four most widespread neurodegenerative diseases are Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and Huntington's disease(HD). Among these, AD is the most prevalent, representing 80% of the total number of dementia cases..
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Ciencias Químicas, leída el 21-04-2023. Tesis formato europeo (compendio de artículos)