New insights into the pathogenesis and transmission of Brucella pinnipedialis: systemic infection in two bottlenose dolphins (Tursiops truncatus)

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dc.contributor.authorVargas Castro, Ignacio
dc.contributor.authorCrespo Picazo, José Luis
dc.contributor.authorFayos, Manena
dc.contributor.authorJiménez Martínez, María De Los Ángeles
dc.contributor.authorTorre Fuentes, Laura
dc.contributor.authorÁlvarez Sánchez, Julio
dc.contributor.authorMoura, André E.
dc.contributor.authorHernández, Marta
dc.contributor.authorBuendía Andrés, Aranzazu
dc.contributor.authorBarroso Arévalo, Sandra
dc.contributor.authorGarcía-Seco Romero, María Teresa
dc.contributor.authorPérez Sancho, Marta
dc.contributor.authorDe Miguel, María Jesús
dc.contributor.authorAndrés Barranco, Sara
dc.contributor.authorMarco Cabedo, Vicente
dc.contributor.authorPeñín Villahoz, Gaizka
dc.contributor.authorMuñoz, Pilar María
dc.contributor.authorDomínguez Rodríguez, Lucas José
dc.contributor.authorGarcía Párraga, Daniel
dc.contributor.authorSánchez-Vizcaíno Rodríguez, José Manuel
dc.date.accessioned2024-05-27T18:03:00Z
dc.date.available2024-05-27T18:03:00Z
dc.date.issued2023-10-06
dc.description.abstractThe emergence of Brucella infections in marine mammals is a growing concern. The present study reports two cases of systemic Brucella pinnipedialis infection detected in bottlenose dolphins (Tursiops truncatus) pair stranded together in the Cantabrian coast of Spain. Both animals showed systemic lesions associated with the Brucella infection, more severe in the younger dolphin, considered the likely offspring of the other individual. Real-time PCR, bacterial culture, and whole-genome sequencing were used to detect and characterize the Brucella strains involved in both dolphins. The phylogenetic analysis performed on the Brucella genomes retrieved revealed that the species involved was B. pinnipedialis (ST25). Both animals resulted seropositive in a commercial multispecies blocking ELISA but tested negative in the standard Rose Bengal test. To the best of our knowledge, this is the first report of a systemic infection resulting in various lesions associated with Brucella pinnipedialis (ST25) in two bottlenose dolphins. It is also the initial isolation of Brucella in the milk of a non-pregnant or non-aborting female cetacean likely stranded with its offspring. These findings provide new insights into the epidemiology and clinical impact of B. pinnipedialis infection in cetaceans and underscore the importance of continued diagnostic surveillance to gain better understanding of brucellosis effects and transmission in marine mammal populations.
dc.description.abstractImportance: Brucella spp. are zoonotic pathogens that can affect both terrestrial and marine mammals. Brucella ceti has been identified in various cetacean species, but only one sequence type (ST27) has been reported in humans. However, it is important to conduct surveillance studies to better understand the impact of marine Brucella species on marine mammals, a typically understudied host group. Here, we describe a systemic infection by two related strains of Brucella pinnipedialis (ST25) in a couple of live-stranded bottlenose dolphins, with more severe lesions in the younger animal. Furthermore, B. pinnipedialis was first detected in milk from a female cetacean that stranded with its offspring. Our study reveals novel insights into the epidemiology and pathological consequences of B. pinnipedialis infections in cetaceans, emphasizing the crucial importance of ongoing surveillance and accurate diagnosis to understand the impact of this pathogen on marine mammal populations.
dc.description.departmentDepto. de Sanidad Animal
dc.description.departmentDepto. de Medicina y Cirugía Animal
dc.description.facultyCentro de Vigilancia Sanitaria Veterinaria (VISAVET)
dc.description.facultyFac. de Veterinaria
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Ciencia, Innovación y Universidades (España)
dc.description.sponsorshipNational Science Centre (Polonia)
dc.description.sponsorshipNational Agency for Academy Exchange (Polonia)
dc.description.statuspub
dc.identifier.citationVargas-Castro I, Crespo-Picazo JL, Fayos M, Jiménez-Martínez MDLÁ, Torre-Fuentes L, Álvarez J, Moura AE, Hernández M, Buendía A, Barroso-Arévalo S, García-Seco T, Pérez-Sancho M, De Miguel MJ, Andrés-Barranco S, Marco-Cabedo V, Peñin-Villahoz G, Muñoz PM, Domínguez L, García-Párraga D, Sánchez-Vizcaíno JM. 2023. New insights into the pathogenesis and transmission of Brucella pinnipedialis: systemic infection in two bottlenose dolphins (Tursiops truncatus). Microbiol Spectr 11:e01997-23. https://doi.org/10.1128/spectrum.01997-23
dc.identifier.doi10.1128/spectrum.01997-23
dc.identifier.essn2165-0497
dc.identifier.officialurlhttps://doi.org/10.1128/spectrum.01997-23
dc.identifier.urihttps://hdl.handle.net/20.500.14352/104474
dc.issue.number6
dc.journal.titleMicrobiology Spectrum
dc.language.isoeng
dc.page.final14
dc.page.initial1
dc.publisherASM
dc.relation.projectIDFPU18/01499
dc.relation.projectID2018/31/D/NZ8/02835
dc.relation.projectIDPPN/ULM/2019/00162
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu579.62
dc.subject.keywordMilk
dc.subject.keywordBrucella pinnipedialis
dc.subject.keywordBottlenose dolphin
dc.subject.keywordMarine mammals
dc.subject.keywordSystemicinfection
dc.subject.keywordHealth surveillance
dc.subject.keywordTransmission
dc.subject.keywordWGS
dc.subject.ucmMicrobiología (Veterinaria)
dc.subject.unesco3109.05 Microbiología
dc.titleNew insights into the pathogenesis and transmission of Brucella pinnipedialis: systemic infection in two bottlenose dolphins (Tursiops truncatus)
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number11
dspace.entity.typePublication
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New insights into the pathogenesis and transmission of Brucella pinnipedialis: systemic infection in two bottlenose dolphins (Tursiops truncatus)
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