Docta Complutense
Open Access Institutional Repository of the Complutense University of Madrid, that compiles scientific production to promote the visibility and impact of Complutense research.
With the collaboration of the Ministerio de Ciencia e Innovación and the Spanish Foundation for Science and Technology (FECYT).
Recent Submissions
In Vivo Functional and Structural Retinal Preservation by Combined Administration of Citicoline and Coenzyme Q10 in a Murine Model of Ocular Hypertension
(International Journal of Molecular Sciences, 2026) Matamoros Felipe, José Antonio; García Martín, Elena Salobrar; Salazar Corral, Juan José; López Cuenca, Inés; Hurtado, Lorena Elvira ; Martínez López, Miguel Ángel; Rubio Casado, Sara; Paleo García, Víctor; Hoz Montañana, María Rosa De; Ramírez Sebastián, José Manuel; Villa, Pedro de la ; Fernández Albarral, José; Ramírez Sebastián, Ana Isabel
This study evaluated the early structural and functional effects of combined citicoline and coenzyme Q10 (CoQ10) (CitiQ10) treatment in a laser-induced ocular hypertension (OHT) model in Swiss albino mice, focusing on retinal inflammation and neuroprotection. Sixty male CD-1 mice were assigned to four groups: vehicle, CitiQ10, OHT, and OHT + CitiQ10. OHT was induced by laser photocoagulation of limbal and episcleral veins, and CitiQ10 was administered orally starting 15 days before induction. Intraocular pressure (IOP) was measured by rebound tonometry, retinal structure was assessed by spectral domain optical coherence tomography (SD-OCT), and function was evaluated using full-field electroretinography (ffERG). At 3 days post-induction, OHT eyes exhibited significant retinal nerve fiber layer (RNFL) thickening, increased vitreous particles, and early functional impairment, particularly reduced scotopic b-wave and oscillatory potentials. CitiQ10 treatment mitigated these changes, reducing vitreous particles, moderating RNFL alterations, and not exhibiting significant changes in ERG amplitudes. At 7 days post-induction, structural and functional deficits persisted but were less pronounced in treated eyes. These findings suggest that CitiQ10 treatment may attenuate early retinal damage in glaucoma, with OCT and ffERG serving as reliable monitoring tools, supporting the therapeutic potential of this approach in early stage disease.
Introduction : Nomadic New Women : Border-Crossing and Intercultural Encounter
(Nomadic New Women : Exile and Border-Crossing between Spain and the Americas, Early to Mid-Twentieth Century, 2024) Silverman, Renée M.; Sánchez-Pardo González, Esther; Silverman, Renée M.; Sánchez-Pardo González, Esther
Harvested by
