Person: Martínez De La Casa Fernández-Borrella, José María
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First Name
José María
Last Name
Martínez De La Casa Fernández-Borrella
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Óptica y Optometría
Department
Inmunología, Oftalmología y ORL
Area
Oftalmología
Identifiers
11 results
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Now showing 1 - 10 of 11
Item Corneal aberrations in primary congenital glaucoma and its visual correlation(International Ophthalmology, 2024) Ly-Yang, Fernando; Morales Fernández, Laura; García Bella, Javier; Garcia Caride, Sara; Santos Bueso, Enrique Miguel; Saenz Frances, Federico; Fernández-Vigo López, José; García Feijoo, Julián; Martínez De La Casa Fernández-Borrella, José MaríaPrimary congenital glaucoma (PCG) can cause permanent vision loss, and its prognosis is related to early detection and treatment. The main pathological defect consists of resistance to aqueous outflow through the trabecular meshwork due to abnormal development of tissue derived from the neural crest in the anterior chamber angle. Even after successful intraocular pressure (IOP) management in PCG poor visual outcomes still present a lifelong challenge. Vision loss in PCG is multifactorial, resulting from optic nerve damage, corneal scarring, and myopic astigmatism associated with anisometropic amblyopia. Although it is already known that children with PCG present with an altered corneal configuration, the knowledge of irregular astigmatism due to high-order aberrations (HOA) and due to the unequal expansion of the anterior segment, and its impact on visual outcomes, is not yet fully understood, to the best of our knowledge. Quality vision is influenced by the presence of aberrations in the eye's optical system, which can degrade the quality of the image projected onto the retina. Low-order aberrations (LOA), including myopia, hyperopia, and regular astigmatism, can be corrected by spectacles, while HOA cannot be corrected by ordinary means. Coma and spherical aberrations are the most visually significant HOAs, while trefoil and other HOAs have a lower impact on visual quality. The purpose of this article is to establish a quantitative correlation between HOA and visual acuity (VA) to measure the magnitude of the impact of the altered cornea on visual outcomes in PCG.Item Corneal Segmentation Analysis Increases Glaucoma Diagnostic Ability of Optic Nerve Head Examination, Heidelberg Retina Tomograph's Moorfield's Regression Analysis, and Glaucoma Probability Score(Journal of Ophthalmology, 2015) Sáenz Francés, Federico; Jañez Escalada, Luis; Berrozpe Villabona, Clara; Borrego Sanz, Lara; Morales Fernández, Laura; Acebal Montero, Alejandra; Méndez Hernández, Carmen D.; Martínez De La Casa Fernández-Borrella, José María; Santos Bueso, Enrique Miguel; García Sánchez, Julián; García Feijoo, JuliánPurpose. To study whether a corneal thickness segmentation model, consisting in a central circular zone of 1 mm radius centered at the corneal apex (zone I) and five concentric rings of 1 mm width (moving outwards: zones II to VI), could boost the diagnostic accuracy of Heidelberg Retina Tomograph's (HRT's) MRA and GPS. Material and Methods. Cross-sectional study. 121 healthy volunteers and 125 patients with primary open-angle glaucoma. Six binary multivariate logistic regression models were constructed (MOD-A1, MOD-A2, MOD-B1, MOD-B2, MOD-C1, and MOD-C2). The dependent variable was the presence of glaucoma. In MOD-A1, the predictor was the result (presence of glaucoma) of the analysis of the stereophotography of the optic nerve head (ONH). In MOD-B1 and MOD-C1, the predictor was the result of the MRA and GPS, respectively. In MOD-B2 and MOD-C2, the predictors were the same along with corneal variables: central, overall, and zones I to VI thicknesses. This scheme was reproduced for model MOD-A2 (stereophotography along with corneal variables). Models were compared using the area under the receiver operator characteristic curve (AUC). Results. MOD-A1-AUC: 0.771; MOD-A2-AUC: 0.88; MOD-B1-AUC: 0.736; MOD-B2-AUC: 0.845; MOD-C1-AUC: 0.712; MOD-C2-AUC: 0.838. Conclusion. Corneal thickness variables enhance ONH assessment and HRT's MRA and GPS diagnostic capacity.Item Correlations between corneal and optic nerve head variables in healthy subjects and patients with primary open angle glaucoma(International journal of ophthalmology, 2015) Sáenz Francés, Federico; Jañez Escalada, Luis; Borrego Sanz, Lara; Berrozpe Villabona, Clara; Martínez De La Casa Fernández-Borrella, José María; Morales Fernández, Laura; García Sánchez, Julián; Santos Bueso, Enrique Miguel; García Feijoo, JuliánAIM: To correlate corneal variables (determined using the Pentacam) with optic nerve head (ONH) variables determined using the Heidelberg retina tomograph (HRT) in healthy subjects and patients diagnosed with primary open angle glaucoma (POAG). METHODS: Measurements were made in 75 healthy eyes and 73 eyes with POAG and correlations examined through Pearson correlation coefficients between the two sets of variables in the two subject groups. The corneal variables determined were corneal volume (CVol), central corneal thickness (CCT), overall corneal thickness (OvCT), the mean thickness of a circular zone centered at the corneal apex of 1 mm radius (zone I) and the mean thickness of several concentric rings, also centered at the apex until the limbus, each of 1 mm width (zones II to VI respectively). The ONH variables were determined using the HRT. RESULTS: The following pairs of variables were correlated in the control group: CCT-disc area (DAr) (-0.48; P<0.0001), Zone I-DAr (-0.503; P<0.0001) and Zone II-DAr (-0.443; P<0.0001); and in the POAG group: CCT-cup-to-disc area ratio (CDRa) (-0.402; P<0.0001), Zone I-CDRa (-0.418; P<0.0001), Zone II-CDRa (-0.405; P=0.006), Zone I-cup shape measure (CSM) (-0.415; P=0.002), Zone II-CSM (-0.405; P=0.001), Zone IV-height variation contour (HVC) (0.378; P=0.002); Zone V-HVC (0.388, P<0.0001). CONCLUSION: AS-OCT-derived lens thickness measurement is valid and comparable to the results obtained by A-scan US. It can be used as a reliable noncontact method for measuring lens thickness in adults with or without significant cataract.Item Cumplimiento del tratamiento del glaucoma(Archivos de la Sociedad Española de Oftalmología, 2014) Santos Bueso, Enrique Miguel; Sáenz Francés, Federico; García Sáenz, Sofía; Méndez Hernández, Carmen D.; Fernández Vidal, Ana M.; Morales Fernández, Laura; Martín Valdizán, Carmen; Martínez De La Casa Fernández-Borrella, José María; García Feijoo, Julián; García Sánchez, JuliánItem Cese paradójico de un caso de síndrome de Charles Bonnet(Archivos de la Sociedad Española de Oftalmología, 2014) Santos Bueso, Enrique Miguel; Serrador García, Mercedes; Sáenz Francés, Federico; Méndez Hernández, Carmen Dora; Martínez De La Casa Fernández-Borrella, José María; García Feijoo, Julián; García Sánchez, JuliánCaso clínico: paciente varón de 78 años diagnosticado de síndrome de Charles Bonnet (SCB) por déficit visual secundario a glaucoma terminal. Evolucionó a amaurosis, presentando desaparición brusca de las alucinaciones de forma paralela a la pérdida del resto visual. Discusión: el cese paradójico del SCB se produce cuando el paciente pierde el resto visual, evolucionando a amaurosis. La falta de estimulación en la retina y el córtex correspondiente hacen desaparecer las alucinaciones debido a que las neuronas desaferentadas e hiperexcitadas pierden el estímulo que desencadena el SCB.Item Changes in corneal biomechanical properties after 24 hours of continuous intraocular pressure monitoring using a contact lens sensor(Canadian Journal of Ophthalmology, 2017) Morales Fernández, Laura; García Bella, Javier; Martínez De La Casa Fernández-Borrella, José María; Sánchez Jean, Rubén; Sáenz Francés, Federico; Arriola Villalobos, Pedro; Perucho González, Lucía; Santos Bueso, Enrique Miguel; García Feijoo, JuliánObjective: This study was designed to assess changes in corneal topography and biomechanics after intraocular pressure (IOP) monitoring using the Triggerfish contact lens sensor (CLS). Methods: For this prospective study, 30 eyes of 30 subjects: 14 healthy subjects (G1) and 6 glaucoma patients (G2), were recruited for 24 hours of continuous IOP monitoring using the CLS. The following measurements were taken before CLS fitting and after lens removal: maximum keratometry (Kmax), mean keratometry (MK), and corneal astigmatism (Cyl) measured through Pentacam corneal topography, and the corneal biomechanical variables corneal hysteresis (CH) and corneal resistance factor (CRF) measured with the Ocular Response Analyzer (ORA). Results: Pentacam data revealed significant changes after CLS removal in Kmax (+3.14 ± 2.46 D, p = 0.002), MK (+0.52 ± 0.63 D, p = 0.02), and Cyl (+0.48 ± 0.53 D, p = 0.019) in G1; and Kmax (+1.38 ± 1.43 D, p = 0.002) in G2. The changes observed were more pronounced in G1 than in G2 but differences were not significant. The ORA results indicated higher CH (11.35 ± 2.42 vs 8.17 ± 2.09) and CRF (10.3 ± 2.03 vs 9.1 ± 1.81) before lens fitting in G1 than G2, while no significant changes were produced after CLS removal in either group. Conclusions: The use of CLS for IOP monitoring over 24 hours caused topographic changes in both healthy subjects and glaucoma patients. No changes were produced in corneal biomechanics.Item Charles Bonnet syndrome in a child with congenital glaucoma(Archivos de la Sociedad Española de Oftalmología, 2017) Santos Bueso, Enrique Miguel; Serrador García, Mercedes; Sáenz Francés, Federico; Méndez Hernández, Carmen Dora; Morales Fernández, Laura; Martínez De La Casa Fernández-Borrella, José María; García Feijoo, Julián; Porta-Etessam, JesúsCase report: The case is presented of a 12 year-old boy with congenital glaucoma and low visual acuity diagnosed with Charles Bonnet syndrome. This consisted of the acute onset of complex, repetitive, persistent, and with visual hallucinations (people, brooms and coffeemakers) of self-limited evolution without treatment. The patient was diagnosed with congenital glaucoma at 3 years of age, and subjected to a trabeculectomy in right eye, and trabeculectomy and keratoplasty in his left eye. Discussion: Charles Bonnet syndrome symptoms have been described in adults, but their presence in children is poorly reflected in literature, with unknown characteristics and prevalence.Item Hipertensión arterial secundaria a tratamiento con latanoprost(Archivos de la Sociedad Española de Oftalmología, 2015) Santos Bueso, Enrique Miguel; Sáenz Francés, Federico; Palmero Fernández, Laura; García Sáenz, Sofía; Martínez De La Casa Fernández-Borrella, José María; García Feijoo, Julián; García Sánchez, JuliánCaso clínico: mujer de 80 años intervenida mediante trabeculectomía por glaucoma primario de ángulo abierto en la que, debido al incremento tensional, se inició tratamiento con latanoprost. La monitorización de la tensión arterial (TA) demostró un incremento estadísticamente significativo de la TA tanto sistólica como diastólica coincidiendo con el uso del hipotensor tópico, que se resolvió al suspender voluntariamente el tratamiento, volviendo a elevarse al reintroducir la prostaglandina. Discusión: los análogos de las prostaglandinas disminuyen la presión intraocular al producir vasodilatación de las arterias ciliares y epiesclerales, aumentando el drenaje del humor acuoso. Los efectos cardiovasculares son poco frecuentes pero se han descrito por el efecto vasoconstrictor que puede desencadenarse como el incremento reversible de la TA de este caso.Item Identificación de estructuras del ángulo iridocorneal mediante tomografía de coherencia óptica de dominio Fourier(Archivos de la Sociedad Española de Oftalmología, 2016) Fernández Vigo, José Ignacio; Fernández Vigo, Cristina; Martínez De La Casa Fernández-Borrella, José María; Sáenz Francés, Federico; Santos Bueso, Enrique Miguel; García Feijoo, Julián; Fernández Vigo, José ÁngelObjetivo: estudiar las estructuras que conforman el ángulo iridocorneal mediante tomografía de coherencia óptica (OCT) de segmento anterior, definiendo sus características tomográficas y cuantificando su frecuencia de identificación. Material y métodos: estudio transversal realizado en 267 ojos derechos de 267 pacientes consecutivos sanos. Se empleó una OCT de dominio Fourier RTVue (Optovue Inc, CA, EE. UU.) para explorar el ángulo iridocorneal en los sectores nasal y temporal. Las estructuras evaluadas fueron: el limbo externo, transición corneoescleral, línea de Schwalbe, malla trabecular, canal de Schlemm, espolón escleral y receso angular. Se calculó la concordancia intra- e interobservador para la identificación de las estructuras mediante el coeficiente kappa. Resultados: la edad media fue 41,3 ± 14,3 años (rango 20-80); el 57% eran mujeres. El limbo externo, la transición córneo-escleral y la línea de Schwalbe se identificaron en un 98,7; 97 y 93,4%, respectivamente de las imágenes. La malla trabecular y el canal de Schlemm se identificaron en el 91% de los casos. El espolón escleral pudo ser identificado en un 85,4% y el receso angular en un 74,5%. No existió diferencia en la identificación entre el sector temporal y nasal. La concordancia intra- e interobservador fue de k=0,92 y k=0,88 respectivamente, en la identificación de las estructuras para el total de las imágenes estudiadas. Conclusiones: la OCT de dominio Fourier es una técnica eficaz para la identificación de las estructuras que conforman el ángulo iridocorneal, entre las que destacan la malla trabecular, el canal de Schlemm, el espolón escleral y la línea de Schwalbe.Item Structural and biomechanical corneal differences between patients suffering from primary congenital glaucoma and healthy volunteers(Acta Ophthalmologica, 2017) Perucho González, Lucía; Sáenz Francés, Federico; Morales Fernández, Laura; Martínez De La Casa Fernández-Borrella, José María; Méndez Hernández, Carmen Dora; Santos Bueso, Enrique Miguel; Brookes, John L.; García Feijoo, JuliánPurpose: To determine whether a set of ocular morphometric and biomechanical variables are able to discriminate between healthy volunteers and patients suffering from primary congenital glaucoma (PCG). Methods: Case-control study in which 66 patients with PCG and 94 age-matched healthy subjects were evaluated using ocular response analyser (ORA) to record corneal biomechanical properties. Topographic corneal variables were obtained using the Pentacam in both groups. To determine the ability to discern between both groups, a multivariate binary logistic model was constructed. The outcome was the diagnosis of PCG and the predictors; the corneal variables analysed along with their first-term interactions. Sensitivity and specificity of this model along with the area under the receiver characteristic operating curve (AUC of ROC) were determined. Results: The best model to discriminate between both groups included the following predictors: corneal hysteresis (CH), corneal resistance factor (CRF), posterior maximum elevation (PME), anterior maximum elevation (AME) and central corneal thickness (CCT). This model, for a cut-point of 50%, presents a sensitivity of 86.67%, a specificity of 86.89% and an AUC of the ROC curve of 93.16% [95% confidence interval (CI): 88.97-97.35]. The adjusted odds ratios of those predictors which showed a significant discriminating capacity were as follows: for CH, 0.27 (95% confidence interval: 0.15-0.46); for CRF, 2.13 (95% CI: 1.33-3.40); for PME, 1.06 (95% CI: 1.01-1.12); and for AME, 1.35 (95% CI: 1.10-1.66). Conclusion: Corneal hysteresis (CH), CRF, PME and AME are able to discern between patients with PCG and healthy controls. This fact suggests that there are structural and biomechanical differences between these groups.