Person: Aragoncillo Abanades, Cristina
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First Name
Cristina
Last Name
Aragoncillo Abanades
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Ciencias Químicas
Department
Química Orgánica
Area
Química Orgánica
Identifiers
7 results
Search Results
Now showing 1 - 7 of 7
Item 2,3‐Diodocarbazoles by a domino iodocyclization/iodo‐translocation of (3‐iodoindolyl)butynols(Advance Synthesis & Catalysis, 2022) Martín‐Mejías, Irene; Petcu, Sonia; Alonso Gómez, José Miguel; Aragoncillo Abanades, Cristina; Almendros Requena, PedroA controlled access to 1‐aryl 2,3‐diiodo‐carbazoles involving iodine transposition has been accomplished directly from acyclic precursors. The 2,3‐diiodo‐carbazole core was prone to further chemoselective decoration at C3−I or double difunctionalization.Item Straightforward Synthesis of Bis[(trifluoromethyl)sulfonyl]ethylated Isocoumarins from 2-Ethynylbenzoates(Journal of Organic Chemistry, 2023) Petcu, Sonia; Lázaro Milla, Carlos; Rodríguez, Javier; Iriepa, Isabel; Bautista-Aguilera, Óscar ; Aragoncillo Abanades, Cristina; Alonso Gómez, José Miguel; Almendros Requena, PedroHerein, we report a facile isocoumarin and isoquinolone preparation by taking advantage of an initial bis(triflyl)ethylation [triflyl = (trifluoromethyl)sulfonyl] reaction, followed by heterocyclization, which contrasts with our previous results on cyclobutene formation. The efficiency of the catalyst- and irradiation-free heterocyclization/bis(triflyl)ethylation sequence showed exquisite dependence on the electronic nature of the substituents at the 2-ethynylbenzoate(benzamide) precursors. Molecular docking of model bis(triflyl)ethylated isocoumarins on human acetylcholinesterase (hAChE) revealed promising biological activities through selective coordination on both the catalytic active site and peripheral active site.Item Synthesis of polycyclic aromatic hydrocarbons decorated by fluorinated carbon acids/carbanions(Chemistry a European Journal, 2021) Hoshikawa, Shoki; Yanai, Hikaru; Martín‐Mejías, Irene; Lázaro Milla, Carlos; Aragoncillo Abanades, Cristina; Almendros Requena, Pedro; Matsumoto, TakashiThe carboarylation reaction of biphenyl‐alkynes was successfully triggered by electrophilic attack of 1,1‐bis(triflyl)ethylene on the alkyne moiety to give polycyclic aromatic hydrocarbons (PAHs) decorated by superacidic carbon acid functionality. Neutralisation of thus obtained acids with NaHCO3 yielded the corresponding sodium salts, which showed improved solubility in both aqueous and organic solvents.Item Palladium‐catalyzed hydroarylation of homopropargyl iodoindoles with concurrent alkyl and iodonium migrations(Advance Synthesis & Catalysis, 2021) Martín, Irene; Aragoncillo Abanades, Cristina; Almendros Requena, PedroA selective palladium‐catalyzed C-arylation/carbocyclization/iodonium migration reaction sequence has been accomplished. Novel 2‐iodo‐1‐aryl‐9-H‐carbazoles are now easily available. As this result is contrary to the selectivity observed using gold catalysis, the formation of 2‐iodocarbazoles is noticeable, suggesting a metal‐controlled cyclization through chemo‐ and regioselective 1,2‐alkyl migration and 1,4‐iodonium migration.Item A catalyst-free bis(triflyl)ethylation/benzannulation reaction: rapid access to carbazole-based superacidic carbon acids from alkynols(Chemical Communications, 2020) Martín-Mejías, Irene; Aragoncillo Abanades, Cristina; Yanai, Hikaru; Hoshikawa, Shoki; Fujimoto, Yuuki; Matsumoto, Takashi; Almendros Requena, PedroCarbazoles possessing Tf2CHCH2 groups were obtained by the reaction of 1-(indol-2-yl)but-3-yn-1-ols with in situ-generated Tf2CQCH2 through vicinal difunctionalisation of the alkyne moiety, where the vinyl-type carbocation intermediate was selectively attacked by the indole moiety and not by the carbanion moietyItem A facile synthesis of blue luminescent [7]helicenocarbazoles bBased on golcatalyzed rearrangement‐iodonium migration and Suzuki–Miyaura benzannulation reactions(Chemistry a European Journal, 2018) Alcaide Alañón, Benito; Almendros Requena, Pedro; Aragoncillo Abanades, Cristina; Busto García, Benjamín Eduardo; López‐Calixto, Carmen ; Liras, Marta; Peña O'Shea, Víctor de la; García‐Sánchez, Alba; Stone, HannahNew azahelicenes having interesting photophysical properties have been prepared in a four‐step sequence. These [7]helicenocarbazoles are efficient blue luminophores, demonstrating the utility of gold catalysis in the preparation of advanced materials.- Project number: 94
Item La química da mucho juego...¿jugamos?(2017) León González, María Eugenia De; Aragoncillo Abanades, Cristina; Luna Costales, Amparo; Martínez Del Campo, Teresa; Rodríguez Yunta, María Josefa; Manuel de Villena Rueda, Francisco Javier; Navarro Villoslada, Fernando; Pérez Arribas, Luis Vicente; Blanco Asenjo, Miriam; Ballesteros de León, Elisa; Gómez Gómez, Beatriz; Moreno Casillas, Gustavo¿Quién no ha jugado alguna vez? ¿Qué juegos conocemos? ¿Podemos motivar a los alumnos a través del juego?. Desde nuestra experiencia durante el curso 2016-2017 y utilizando adaptaciones de dos juegos tradicionales de mesa podemos observar que los alumnos participan y aprenden jugando y que el profesor puede utilizar el juego para evaluar las competencias y habilidades de los participantes. Con el juego los docentes dejamos de ser el centro de la clase o del laboratorio y pasamos a ser meros conductores del proceso de aprendizaje además de facilitar el trabajo en pequeños grupos. Los juegos utilizados son una adaptación de juegos de mesa que utilizan preguntas relacionadas con la Química. Se ha desarrollado material didáctico en forma de cartulinas con cuatro tipos de preguntas adaptadas a diferentes asignaturas de diferentes grados y que se pueden utilizar tanto en el laboratorio de prácticas como en el aula. Los juegos se han utilizado en asignaturas de los grados de Química, Biología e Ingeniería Química en tutorías, seminarios o en el laboratorio o bien al final del mismo o durante los periodos en los que los alumnos tienen “tiempos muertos” dado el desarrollo de las prácticas.