Diseño, caracterización y evaluación biológica de diferentes nano-micropartículas poliméricas como sistemas de liberación controlada de tamoxifeno

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Universidad Complutense de Madrid
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Conventional drugs present good results in numerous pathologies, but in some cases, these dosage forms have serious limitations (limited solubility, low absorption and bioavailability of active pharmaceutical ingredient). Controlled release systems can improve these limitations and they also present a large number of advantages which make them indispensable for treatments of certain diseases such as cancer and diabetes among others. In these systems, the drug is release in a control manner at therapeutic concentrations and the release pattern can be established for certain periods of time. Among the multiparticulated controlled systems the nanoparticles and nanohydrogels, are taking an increasing interest due to their versatility in pharmaceutical applications and their properties, which provide numerous advantages. They can be made of different types of polymers from synthetic to natural polymers, which facilitate the modulation of characteristics according to the needs. Polymers, therefore, are release controlling materials that will determine some of the system specifications. To design, synthesize and develop these controlled release systems is necessary to take into account a number of pharmaceutical considerations like: type of polymers, the synthesis method, particle sizes, amount of incorporated drug, amount of drug released (in vitro and in vivo), drug and system stability, surface properties, antigenicity, toxicity, the drug and delivery system biokinetics. One of the features provided by these systems is the capacity of vectorization for drug targeting with a biologic molecule. A higher therapeutic efficiency is obtained with fewer side effects through specific release at the target site, which has great potential for cancer treatment. One of the molecules used as a vector is the folic acid that has shown greater specificity to some tumor cells that over express folate receptors. Cancer is a disease with a higher incidence and high mortality. The treatment of this pathology is, many times, limited by the tumors characteristics or the selected drug. One of the treatments of choice is the chemotherapy, by the administration of cytostatic drugs. In many cases, this treatment has low therapeutic efficacy with low specificity leading to numerous side effects...
Tesis inédita de la Universidad Complutense de Madrid, Facultad de Farmacia, leída el 24-09-2015
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