Brown marine algae Gongolaria baccata extract protects Caco-2 cells from oxidative stress induced by tert-butyl hydroperoxide

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dc.contributor.authorMartínez Caballero, María Aranzazu
dc.contributor.authorAres Lombán, Irma
dc.contributor.authorMartínez Caballero, Marta
dc.contributor.authorLópez Torres, Bernardo
dc.contributor.authorMaximiliano Guerra, Jorge Enrique
dc.contributor.authorRodriguez, J.L
dc.contributor.authorMartínez Larrañaga, María Rosa
dc.contributor.authorAnadón Navarro, Arturo Ramón
dc.contributor.authorPeteiro, C.
dc.contributor.authorRubiño, S
dc.contributor.authorHortos, M
dc.date.accessioned2024-02-01T12:35:04Z
dc.date.available2024-02-01T12:35:04Z
dc.date.issued2021-08-01
dc.description.abstractGongolaria baccata (S.G. Gmelin) is marine brown seaweed mainly found on the coasts of the Baltic Sea south to the Mediterranean Sea, Canary Islands, Mauritania and Western Sahara. Herein, we report the cell viability and protective effects attributed to molecular mechanisms underlying antioxidant response to survive oxidative stress injuries. Caco-2 cells were submitted to oxidative stress by treatment with tert-butylhydroperoxide (tert-BOOH). The extract prevented cell damage and enhanced activity of antioxidant defenses (NQO1 and GST activities and GSH levels) reduced by treatment with tert-BOOH. The increases of MDA levels, the amount of intracellular ROS and caspase 3/7 activity induced by tert-BOOH were prevented when cells were treated with the G. baccata extract. Moreover, G. baccata extract caused up-regulation of GSTM2, Nrf2, and AKT1 gene expressions, as well as G. baccata extract reduced significantly Bax, BNIP3, APAF1, ERK1, JNK1, MAPK1, P38, P53, NFκB1, TNFα, IL-6, IL-1β and HO-1 gene expressions related to apoptosis, proinflammation and oxidative stress induced by tert-BOOH. These results suggest that G.baccata extract protected the cells against oxidative damage and inflammation; protective effects that could be linked to their bioactive constituents. Hence, this brown seaweed G. baccata extract could be used for the development of functional foods and/or nutraceuticals.
dc.description.departmentDepto. de Farmacología y Toxicología
dc.description.facultyFac. de Veterinaria
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Economía, Industria y Competitividad (España)
dc.description.sponsorshipMinisterio de Ciencia e Innovación (España)
dc.description.statuspub
dc.identifier.citationMartínez MA, Ares I, Martínez M, Lopez-Torres B, Maximiliano JE, Rodríguez JL, Martínez-Larrañaga MR, Anadón A, Peteiro C, Rubiño S, Hortos M. Brown marine algae Gongolaria baccata extract protects Caco-2 cells from oxidative stress induced by tert-butyl hydroperoxide. Food Chem Toxicol. 2021 Oct;156:112460. doi: 10.1016/j.fct.2021.112460. Epub 2021 Aug 1. PMID: 34348126.
dc.identifier.doi10.1016/j.fct.2021.112460
dc.identifier.issn0278-6915
dc.identifier.officialurlhttps://www.sciencedirect.com/science/article/pii/S0278691521004932
dc.identifier.pmid34348126
dc.identifier.urihttps://hdl.handle.net/20.500.14352/97677
dc.issue.number112460
dc.journal.titleFood and Chemical Toxicology
dc.language.isoeng
dc.publisherElsevier
dc.relation.projectIDRTA2015-00010-C03
dc.relation.projectIDPID 2020-15979RR-C33
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu615.9
dc.subject.keywordG. baccata extract
dc.subject.keywordPhenolic and carbohydrate derivatives
dc.subject.keywordOxidative stress
dc.subject.keywordCaco-2 cells
dc.subject.ucmCiencias Biomédicas
dc.subject.unesco3214 Toxicología
dc.titleBrown marine algae Gongolaria baccata extract protects Caco-2 cells from oxidative stress induced by tert-butyl hydroperoxide
dc.typejournal article
dc.type.hasVersionAM
dc.volume.number156
dspace.entity.typePublication
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