Latent Microsporidia Infection Prevalence as a Risk Factor in Colon Cancer Patients

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dc.contributor.authorRedondo Martínez, Fernando
dc.contributor.authorHurtado-Marcos, Carolina
dc.contributor.authorIzquierdo Arias, Fernando
dc.contributor.authorCuéllar Del Hoyo, María Del Carmen
dc.contributor.authorFenoy Rodríguez, Soledad
dc.contributor.authorSáez Álvarez, Yanira
dc.contributor.authorMagnet Dávila, Ángela
dc.contributor.authorGalindo-Regal, Lorena
dc.contributor.authorUribe, Natalia
dc.contributor.authorLópez-Bañeres, Manuel
dc.contributor.authorJiménez, Ana Isabel
dc.contributor.authorLlombart-Cussac, Antonio
dc.contributor.authorÁguila De La Fuente, Carmen Del
dc.contributor.authorAndreu-Ballester, Juan Carlos
dc.date.accessioned2024-02-15T10:44:09Z
dc.date.available2024-02-15T10:44:09Z
dc.date.issued2022-10-29
dc.description.abstractMicrosporidia are opportunistic intracellular parasites, generating serious pathology in individuals with a compromised immune system. Infection by microsporidia inhibits p53 and Caspase 3, proteins involved in apoptosis and the cell cycle, which are vital in the malignant process of epithelial cells. The presence of microsporidia in the intestinal tissues of 87 colon cancer (CC) patients and 25 healthy controls was analyzed by real-time PCR and an immunofluorescence antibody test. Anti-Encephalitozoon antibodies were analyzed in serum samples by ELISA (enzyme linked immunosorbent assay). In 36 (41.3%) CC cases, microsporidia infections were identified in their tissues vs. no cases among control subjects (p &lt; 0.0001). An increase in IgG and IgE anti-Encephalitozoon antibodies was found in patients with CC, which would demonstrate continuous and previous contact with the parasite. The high prevalence of microsporidia in tissues and the seroprevalence in patients with CC suggest a relationship between microsporidia and the etiopathogenesis of CC.</jats:p>
dc.description.departmentDepto. de Microbiología y Parasitología
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.sponsorshipBanco Santander Foundation-CEU Foundation
dc.description.statuspub
dc.identifier.citationRedondo F, Hurtado-Marcos C, Izquierdo F, Cuéllar C, Fenoy S, Sáez Y, Magnet Á, Galindo-Regal L, Uribe N, López-Bañeres M, Jiménez AI, Llombart-Cussac A, Del Águila C, Andreu-Ballester JC. Latent Microsporidia Infection Prevalence as a Risk Factor in Colon Cancer Patients. Cancers (Basel). 2022 Oct 29;14(21):5342. doi: 10.3390/cancers14215342. PMID: 36358760; PMCID: PMC9658866.
dc.identifier.doi10.3390/cancers14215342
dc.identifier.issn2072-6694
dc.identifier.officialurlhttps://doi.org/10.3390/cancers14215342
dc.identifier.urihttps://hdl.handle.net/20.500.14352/101465
dc.issue.number21
dc.journal.titleCancers
dc.language.isoeng
dc.page.initial5342
dc.publisherMDPI
dc.relation.projectIDinfo:eu-repo/grantAgreement/FUSP-BS-PPC11/2014
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu615.28
dc.subject.cdu616-006.04
dc.subject.cdu615.01/.03
dc.subject.keywordMicrosporidia
dc.subject.keywordEncephalitozoon sp
dc.subject.keywordEnterocytozoon bieneusi
dc.subject.keywordColon cancer
dc.subject.keywordIFAT
dc.subject.keywordELISA
dc.subject.ucmCiencias Biomédicas
dc.subject.ucmMicrobiología (Farmacia)
dc.subject.ucmParasitología (Farmacia)
dc.subject.unesco3207.12 Parasitología
dc.titleLatent Microsporidia Infection Prevalence as a Risk Factor in Colon Cancer Patients
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number14
dspace.entity.typePublication
relation.isAuthorOfPublication6c555fb4-e29c-4463-8062-a9699fcebaa6
relation.isAuthorOfPublication.latestForDiscovery6c555fb4-e29c-4463-8062-a9699fcebaa6
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