Latent Microsporidia Infection Prevalence as a Risk Factor in Colon Cancer Patients

Redondo Martínez, Fernando; Hurtado-Marcos, Carolina; Izquierdo Arias, Fernando; Cuéllar Del Hoyo, María Del Carmen; Fenoy Rodríguez, Soledad; Sáez Álvarez, Yanira; Magnet Dávila, Ángela; Galindo-Regal, Lorena; Uribe, Natalia; López-Bañeres, Manuel; Jiménez, Ana Isabel; Llombart-Cussac, Antonio; Águila De La Fuente, Carmen Del; Andreu-Ballester, Juan Carlos

Latent Microsporidia Infection Prevalence as a Risk Factor in Colon Cancer Patients

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REDONDO ET AL 2022 CANCERS.pdf (685.24 KB)

Official URL

https://doi.org/10.3390/cancers14215342

Publication date

2022

Authors

Redondo Martínez, Fernando

Hurtado-Marcos, Carolina

Izquierdo Arias, Fernando

Cuéllar Del Hoyo, María Del Carmen

Fenoy Rodríguez, Soledad

Sáez Álvarez, Yanira

Magnet Dávila, Ángela

Galindo-Regal, Lorena

Uribe, Natalia

López-Bañeres, Manuel

Publisher

MDPI

Citations

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URI

https://hdl.handle.net/20.500.14352/101465

Citation

Redondo F, Hurtado-Marcos C, Izquierdo F, Cuéllar C, Fenoy S, Sáez Y, Magnet Á, Galindo-Regal L, Uribe N, López-Bañeres M, Jiménez AI, Llombart-Cussac A, Del Águila C, Andreu-Ballester JC. Latent Microsporidia Infection Prevalence as a Risk Factor in Colon Cancer Patients. Cancers (Basel). 2022 Oct 29;14(21):5342. doi: 10.3390/cancers14215342. PMID: 36358760; PMCID: PMC9658866.

Abstract

Microsporidia are opportunistic intracellular parasites, generating serious pathology in individuals with a compromised immune system. Infection by microsporidia inhibits p53 and Caspase 3, proteins involved in apoptosis and the cell cycle, which are vital in the malignant process of epithelial cells. The presence of microsporidia in the intestinal tissues of 87 colon cancer (CC) patients and 25 healthy controls was analyzed by real-time PCR and an immunofluorescence antibody test. Anti-Encephalitozoon antibodies were analyzed in serum samples by ELISA (enzyme linked immunosorbent assay). In 36 (41.3%) CC cases, microsporidia infections were identified in their tissues vs. no cases among control subjects (p < 0.0001). An increase in IgG and IgE anti-Encephalitozoon antibodies was found in patients with CC, which would demonstrate continuous and previous contact with the parasite. The high prevalence of microsporidia in tissues and the seroprevalence in patients with CC suggest a relationship between microsporidia and the etiopathogenesis of CC.