The Role of Autophagy in Eye Diseases

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dc.contributor.authorFernández Albarral, José
dc.contributor.authorDe Julián López, Esther
dc.contributor.authorSoler Domínguez, Carmen
dc.contributor.authorHoz Montañana, María Rosa De
dc.contributor.authorLópez Cuenca, Inés
dc.contributor.authorGarcía Martín, Elena Salobrar
dc.contributor.authorRamírez Sebastián, José Manuel
dc.contributor.authorPinazo Durán, María Dolores
dc.contributor.authorSalazar Corral, Juan José
dc.contributor.authorRamírez Sebastián, Ana Isabel
dc.dateReceived: 6 February 2021 / Revised: 23 February 2021 / Accepted: 24 February 2021 / Published: 27 February 2021
dc.date.accessioned2023-06-17T08:59:45Z
dc.date.available2023-06-17T08:59:45Z
dc.date.issued2021-02-27
dc.descriptionThis research was funded by the Ophthalmological Network OFTARED (Enfermedades oculares: Prevención, detección precoz, tratamiento y rehabilitación de las patologías oculares) (RD16/0008/0005 and RD16/0008/0026) of the Institute of Health of Carlos III of the Spanish Ministry of Economy and by the European programme FEDER; and Network RETiBRAIN (La retina un modelo para investigar Neuroprotección en patologías del Sistema Nervioso Central) (RED2018-102499-T) of Spanish Ministry of Science and Innovation. And J.A.F.-A. is currently funded by a Predoctoral Fellowship (FPU17/01023) from the Spanish Ministry of Science, Innovation, and Universities; and I.L.-C. is currently funded by a Predoctoral Fellowship (CT42/18-CT43/18) from the Complutense University of Madrid.
dc.description.abstractAutophagy is a catabolic process that ensures homeostasis in the cells of our organism. It plays a crucial role in protecting eye cells against oxidative damage and external stress factors. Ocular pathologies of high incidence, such as age-related macular degeneration, cataracts, glaucoma, and diabetic retinopathy are of multifactorial origin and are associated with genetic, environmental factors, age, and oxidative stress, among others; the latter factor is one of the most influential in ocular diseases, directly affecting the processes of autophagy activity. Alteration of the normal functioning of autophagy processes can interrupt organelle turnover, leading to the accumulation of cellular debris and causing physiological dysfunction of the eye. The aim of this study is to review research on the role of autophagy processes in the main ocular pathologies, which have a high incidence and result in high costs for the health system. Considering the role of autophagy processes in cell homeostasis and cell viability, the control and modulation of autophagy processes in ocular pathologies could constitute a new therapeutic approach.en
dc.description.departmentUnidad Docente de Inmunología, Oftalmología y ORL
dc.description.facultyFac. de Óptica y Optometría
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Economía, Comercio y Empresa (España)
dc.description.sponsorshipMinisterio de Ciencia, Innovación y Universidades (España)
dc.description.sponsorshipInstituto de Salud Carlos III
dc.description.sponsorshipFondo Europeo de Desarrollo Regional
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/64228
dc.identifier.citationFernández Albarral, J. A., De Julián López, E., Soler Domínguez, C. et al. «The Role of Autophagy in Eye Diseases». Life, vol. 11, n.o 3, febrero de 2021, p. 189. DOI.org (Crossref), https://doi.org/10.3390/life11030189.
dc.identifier.doi10.3390/life11030189
dc.identifier.issn2075-1729
dc.identifier.officialurlhttps://doi.org/10.3390/life11030189
dc.identifier.relatedurlhttps://www.mdpi.com/2075-1729/11/3/189
dc.identifier.urihttps://hdl.handle.net/20.500.14352/7861
dc.issue.number3
dc.journal.titleLife
dc.language.isoeng
dc.publisherMultidisciplinary Digital Publishing Institute
dc.relation.projectIDOFTARED (RD16/0008/0005 and RD16/0008/0026)
dc.relation.projectIDRETiBRAIN (RED2018- 102499-T
dc.relation.projectIDFPU17/01023
dc.relation.projectIDCT42/18-CT43/18
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu576.385:617.7
dc.subject.cdu617.7-007.681
dc.subject.cdu617.741-004.1
dc.subject.keywordAutophagy
dc.subject.keywordOcular pathology
dc.subject.keywordGlaucoma
dc.subject.keywordCataract
dc.subject.keywordDiabetic retinopathy
dc.subject.keywordAMD
dc.subject.ucmOftalmología
dc.subject.ucmBiología celular (Biología)
dc.subject.unesco3201.09 Oftalmología
dc.subject.unesco2407 Biología Celular
dc.titleThe Role of Autophagy in Eye Diseasesen
dc.typejournal article
dc.volume.number11
dspace.entity.typePublication
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