The Role of Autophagy in Eye Diseases

Fernández Albarral, José; De Julián López, Esther; Soler Domínguez, Carmen; Hoz Montañana, María Rosa De; López Cuenca, Inés; García Martín, Elena Salobrar; Ramírez Sebastián, José Manuel; Pinazo Durán, María Dolores; Salazar Corral, Juan José; Ramírez Sebastián, Ana Isabel

The Role of Autophagy in Eye Diseases

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Salobrar_2021_life-11-00189.pdf (1.11 MB)

Official URL

https://doi.org/10.3390/life11030189

Publication date

2021

Authors

Fernández Albarral, José

De Julián López, Esther

Soler Domínguez, Carmen

Hoz Montañana, María Rosa De

López Cuenca, Inés

García Martín, Elena Salobrar

Ramírez Sebastián, José Manuel

Pinazo Durán, María Dolores

Salazar Corral, Juan José

Ramírez Sebastián, Ana Isabel

Publisher

Multidisciplinary Digital Publishing Institute

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URI

https://hdl.handle.net/20.500.14352/7861

Citation

Fernández Albarral, J. A., De Julián López, E., Soler Domínguez, C. et al. «The Role of Autophagy in Eye Diseases». Life, vol. 11, n.o 3, febrero de 2021, p. 189. DOI.org (Crossref), https://doi.org/10.3390/life11030189.

Abstract

Autophagy is a catabolic process that ensures homeostasis in the cells of our organism. It plays a crucial role in protecting eye cells against oxidative damage and external stress factors. Ocular pathologies of high incidence, such as age-related macular degeneration, cataracts, glaucoma, and diabetic retinopathy are of multifactorial origin and are associated with genetic, environmental factors, age, and oxidative stress, among others; the latter factor is one of the most influential in ocular diseases, directly affecting the processes of autophagy activity. Alteration of the normal functioning of autophagy processes can interrupt organelle turnover, leading to the accumulation of cellular debris and causing physiological dysfunction of the eye. The aim of this study is to review research on the role of autophagy processes in the main ocular pathologies, which have a high incidence and result in high costs for the health system. Considering the role of autophagy processes in cell homeostasis and cell viability, the control and modulation of autophagy processes in ocular pathologies could constitute a new therapeutic approach.

Description

This research was funded by the Ophthalmological Network OFTARED (Enfermedades oculares: Prevención, detección precoz, tratamiento y rehabilitación de las patologías oculares) (RD16/0008/0005 and RD16/0008/0026) of the Institute of Health of Carlos III of the Spanish Ministry of Economy and by the European programme FEDER; and Network RETiBRAIN (La retina un modelo para investigar Neuroprotección en patologías del Sistema Nervioso Central) (RED2018-102499-T) of Spanish Ministry of Science and Innovation. And J.A.F.-A. is currently funded by a Predoctoral Fellowship (FPU17/01023) from the Spanish Ministry of Science, Innovation, and Universities; and I.L.-C. is currently funded by a Predoctoral Fellowship (CT42/18-CT43/18) from the Complutense University of Madrid.