Publication: Papel del sistema purinérgico en el desarrollo de la corteza cerebral humana basado en un modelo de organoides cerebrales
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2024-04-24
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Universidad Complutense de Madrid
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Abstract
El desarrollo de la corteza cerebral humana es un proceso complejo y dinámico que implica una secuencia de eventos genéticos, físicos, bioquímicos y medioambientales estrechamente coordinados, cuyas alteraciones pueden llevar asociadas la aparición de anomalías cerebrales que se denominan conjuntamente Malformaciones en el Desarrollo Cortical (MCD) (Guerrini and Dobyns, 2014). Con la finalidad de diseñar estrategias terapéuticas efectivas que contrarresten las deficiencias asociadas a las MCD, resulta primordial desentrañar los mecanismos moleculares que controlan el desarrollo de la corteza cerebral humana. Esto implica una profunda caracterización de la población celular principal que impulsa el desarrollo cortical, la Glía Radial o células madre neurales (NSCs). Sin embargo, la mayoría de los estudios realizados hasta la fecha han utilizado modelos animales o se han realizado en poblaciones individuales de subtipos celulares corticales derivados de células madre humanas, en lugar de analizar en conjunto todos los tipos celulares que constituyen la cito-arquitectura de la corteza cerebral (Conti and Cattaneo, 2010, Hansen et al., 2010, Lancaster and Knoblich, 2014b)...
The development of the human cerebral cortex is a complex and dynamic process that involves a sequence of closely coordinated genetic, physical, biochemical and environmental events, whose alterations can lead to brain abnormalities collectively referred to as Malformations of cortical development (MCDs) (Guerrini and Dobyns, 2014). In order to design effective therapeutic strategies to counteract the deficiencies associated with MCDs, it is essential to unravel the molecular mechanisms that control the development of the human cerebral cortex. This involves a deep characterization of the main cellular population driving cortical development, the Radial Glia (RG) or neural stem cells (NSCs). However, most studies to date have used animal models or have been carried out on individual populations of human stem cell-derived cortical cell subtypes, rather than analysing as a whole all cell types that constitute the cytoarchitecture of the cerebral cortex (Conti and Cattaneo, 2010, Hansen et al., 2010, Lancaster and Knoblich, 2014b)...
The development of the human cerebral cortex is a complex and dynamic process that involves a sequence of closely coordinated genetic, physical, biochemical and environmental events, whose alterations can lead to brain abnormalities collectively referred to as Malformations of cortical development (MCDs) (Guerrini and Dobyns, 2014). In order to design effective therapeutic strategies to counteract the deficiencies associated with MCDs, it is essential to unravel the molecular mechanisms that control the development of the human cerebral cortex. This involves a deep characterization of the main cellular population driving cortical development, the Radial Glia (RG) or neural stem cells (NSCs). However, most studies to date have used animal models or have been carried out on individual populations of human stem cell-derived cortical cell subtypes, rather than analysing as a whole all cell types that constitute the cytoarchitecture of the cerebral cortex (Conti and Cattaneo, 2010, Hansen et al., 2010, Lancaster and Knoblich, 2014b)...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Veterinaria, leída el 23/11/2023