Unveiling the value of C-reactive Protein as a Severity Biomarker and the IL4/IL13 Pathway as a Therapeutic Target in Recessive Dystrophic Epidermolysis Bullosa: a multiparametric cross-sectional study

Quintana Castanedo, Lucía; Sánchez Ramón, Silvia María; Illera, Nuria; Zuluaga Arias, María Del Pilar; Martínez Santamaría, Lucía; Fernández Arquero, Miguel; Río, Marcela del; Vicente López, María Ángeles; Escámez, María José; Sacedón Ayuso, Rosa

Unveiling the value of C-reactive Protein as a Severity Biomarker and the IL4/IL13 Pathway as a Therapeutic Target in Recessive Dystrophic Epidermolysis Bullosa: a multiparametric cross-sectional study

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Official URL

https://doi.org/10.1111/exd.15146

Publication date

2024

Publisher

Willey

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URI

https://hdl.handle.net/20.500.14352/107670

Citation

Quintana-Castanedo L, Sánchez-Ramón S, Maseda R, et al. Unveiling the value of C-reactiveprotein as a severity biomarker and the IL4/IL13 pathway asa therapeutic target in recessive dystrophic epidermolysisbullosa: A multiparametric cross-sectional study. ExpDermatol. 2024;33:e15146. doi:10.1111/exd.15146help

Abstract

Patients with recessive dystrophic epidermolysis bullosa (RDEB) experience numerous complications, which are exacerbated by inflammatory dysregulation and infection. Understanding the immunological mechanisms is crucial for selecting medications that balance inflammation control and immunocompetence. In this cross-sectional study, aiming to identify potential immunotherapeutic targets and inflammatory biomarkers, we delved into the interrelationship between clinical severity and systemic inflammatory parameters in a representative RDEB cohort. Encompassing 84 patients aged 1 to 67 and spanning all three Epidermolysis Bullosa Disease Activity and Scarring Index (EBDASI) severity categories, we analyzed the interrelationship of infection history, standard inflammatory markers, systemic cytokines, and Ig levels to elucidate their roles in RDEB pathophysiology. Our findings identify C-reactive protein as an excellent biomarker for disease severity in RDEB. A Type 2 inflammatory profile prevails among moderate and severe RDEB patients, correlating with dysregulated circulating IgA and IgG. These results underscore the IL4/IL13 pathways as potential evidence-based therapeutic targets. Moreover, the complete inflammatory scenario aligns with Staphylococcus aureus virulence mechanisms. Concurrently, abnormalities in IgG, IgE, and IgM levels suggest an immunodeficiency state in a substantial number of the cohort's patients. Our results provide new insights into the interplay of infection and immunological factors in the pathogenesis of RDEB.