Metabolomic study of plasma of patients with abdominal aortic aneurysm
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Publication date
2012
Authors
Rupérez, Francisco J.
Ramos-Mozo, Priscila
Teul, Joanna
Martinez-Pinna, Roxana
Garcia, Antonia
Malet-Martino, Myriam
Camafeita, Emilio
Lopez, Juan Antonio
Egido, Jesús
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Springer
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Rupérez FJ, Ramos-Mozo P, Teul J, Martinez-Pinna R, Garcia A, Malet-Martino M, Camafeita E, Lopez JA, Pastor-Vargas C, Egido J, Balayssac S, Gilard V, Barbas C, Martin-Ventura JL. Metabolomic study of plasma of patients with abdominal aortic aneurysm. Anal Bioanal Chem. 2012 Jun;403(6):1651-60. doi: 10.1007/s00216-012-5982-y. Epub 2012 Apr 29. PMID: 22543712.
Abstract
Abdominal aortic aneurysm (AAA) is an important health problem, both because of AAA rupture and death and because of increased cardiovascular mortality. Identification of new biomarkers of AAA may suggest novel pathological mechanisms and targets for new medical treatments to slow AAA progression. Metabolic changes in AAA patients were mainly related to carbohydrate and lipid metabolism and many of these changes can be associated with a situation of insulin resistance (which can be related to metabolic syndrome) together with altered amino acid metabolism. For the first time, metabolites that can be associated with differential metabolism by the gut microflora of AAA patients have also been found. Moreover, aminomalonic acid in plasma has been shown to be the metabolite with the biggest difference between patients suffering from large aneurysm (>5 cm) and controls.