Strength and medium-term impact of HisAK70 immunization in dogs: Vaccine safety and biomarkers of effectiveness for ex vivo Leishmania infantum infection

Simple item page
dc.contributor.authorMartínez Rodrigo, Abel
dc.contributor.authorMas Zubiri, Alicia
dc.contributor.authorFernández-Cotrina, Javier
dc.contributor.authorBelinchón-Lorenzo, Silvia
dc.contributor.authorOrden Gutiérrez, José Antonio
dc.contributor.authorArias, Pablo
dc.contributor.authorFuente López, Ricardo De La
dc.contributor.authorCarrión Herrero, Francisco Javier
dc.contributor.authorDomínguez Bernal, Gustavo Ramón
dc.date.accessioned2024-01-11T14:27:06Z
dc.date.available2024-01-11T14:27:06Z
dc.date.issued2019
dc.description.abstractHisAK70 candidates have successfully been tested in cutaneous (CL) and visceral leishmaniosis (VL) mouse models. Here, we analyse different biomarkers in dog trials after a heterologous immunization strategy with a HisAK70 candidate (plasmid DNA plus adoptive transfer of peripheral blood-derived dendritic cells (DCs) pulsed with the same pathoantigen and CpG ODN as an adjuvant) to explore the antileishmanial activity in an ex vivo canine co-culture system in the presence of Leishmania infantum parasites. In the canine model, the heterologous HisAK70 vaccine could decrease the infection index in the DC-T cell co-culture system by up to 54% after 30 days and reach almost 67% after 100 days post-immunization, respectively, compared to those obtained in the control group of dogs. The observed security and potential to fight ex vivo L. infantum infection highlight a HisAK70 heterologous immunization strategy as a promising alternative to evaluate its effectiveness against canine VL.
dc.description.departmentDepto. de Sanidad Animal
dc.description.facultyFac. de Veterinaria
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Economía y Competitividad (España)
dc.description.sponsorshipComunidad de Madrid
dc.description.statuspub
dc.identifier.citationMolina-Rueda F, Fernández-González P, Cuesta-Gómez A, Koutsou A, Carratalá-Tejada M, Miangolarra JC. Test-Retest Reliability of a Conventional Gait Model for Registering Joint Angles during Initial Contact and Toe-Off in Healthy Subjects. Int J Environ Res Public Health. 2021 Feb 15;3(18):1343-52
dc.identifier.doi10.1016/j.cimid.2019.05.009
dc.identifier.issn0147-9571
dc.identifier.officialurlhttps://doi.org/10.1016/j.cimid.2019.05.009
dc.identifier.relatedurlhttps://www.sciencedirect.com/science/article/pii/S0147957119300888?
dc.identifier.urihttps://hdl.handle.net/20.500.14352/92568
dc.journal.titleComparative Immunology, Microbiology and Infectious Diseases
dc.language.isoeng
dc.page.final143
dc.page.initial137
dc.publisherElsevier
dc.relation.projectID(AGL2013-44100R) MINISTERIO DE ECONOMÍA Y COMPETITIVIDAD
dc.relation.projectIDPLATESA (S2013/ABI-2906) COMUNIDAD DE MADRID
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsrestricted access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu636.09:615.37
dc.subject.keywordZoonotic infection
dc.subject.keywordVisceral leishmaniosis
dc.subject.keywordDogs
dc.subject.keywordVaccination
dc.subject.keywordHisAK70
dc.subject.keywordDendriticcells
dc.subject.keywordCanineleishmaniosis
dc.subject.ucmCiencias Biomédicas
dc.subject.unesco32 Ciencias Médicas
dc.titleStrength and medium-term impact of HisAK70 immunization in dogs: Vaccine safety and biomarkers of effectiveness for ex vivo Leishmania infantum infection
dc.typejournal article
dc.type.hasVersionSMUR
dc.volume.number65
dspace.entity.typePublication
relation.isAuthorOfPublication032c721f-5804-4b94-b573-701af816cfe2
relation.isAuthorOfPublicationc870c8b8-1a25-476d-8e05-2ac13abf6aef
relation.isAuthorOfPublication877dc9b2-b782-4439-9f51-7e19648b8ed5
relation.isAuthorOfPublication3bea4bef-fc38-4c7e-a6b3-a0b8f278f563
relation.isAuthorOfPublication8207c445-ff65-45fc-9070-60fe6e14b5e2
relation.isAuthorOfPublicationabaef580-f831-4742-bfe3-1e02ba3a6594
relation.isAuthorOfPublication.latestForDiscovery032c721f-5804-4b94-b573-701af816cfe2
Download
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
HisAK70_immunization_in_dogs.pdf
Size:
622.92 KB
Format:
Adobe Portable Document Format
Download
Collections
Artículos