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Neuroestradiol and neuronal development: not an exclusive male tale anymore

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dc.contributor.authorGarcía Segura, Luis M.
dc.contributor.authorMéndez, Pablo
dc.contributor.authorArévalo, M. Angeles
dc.contributor.authorAzcoitia Elías, Íñigo
dc.date.accessioned2025-06-18T15:56:03Z
dc.date.available2025-06-18T15:56:03Z
dc.date.issued2023-09
dc.descriptionFunding: This study has been supported by Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain and by PID2020-115019RB-I00 and PID2020-112824GB-I00 funded by MCIN/AEI/ https://doi.org/10.13039/501100011033 and Fondo Europeo de Desarrollo Regional (FEDER).
dc.description.abstractThe brain synthesizes a variety of neurosteroids, including neuroestradiol. Inhibition of neuroestradiol synthesis results in alterations in basic neurodevelopmental processes, such as neurogenesis, neuroblast migration, neuritogenesis and synaptogenesis. Although the neurodevelopmental actions of neuroestradiol are exerted in both sexes, some of them are sex-specific, such as the well characterized effects of neuroestradiol derived from the metabolism of testicular testosterone during critical periods of male brain development. In addition, recent findings have shown sex-specific actions of neuroestradiol on neuroblast migration, neuritic growth and synaptogenesis in females. Among other factors, the epigenetic regulation exerted by X linked genes, such as Kdm6a/Utx, may determine sex-specific actions of neuroestradiol in the female brain. This review evidences the impact of neuroestradiol on brain formation in both sexes and highlights the interaction of neural steriodogenesis, hormones and sex chromosomes in sex-specific brain development.
dc.description.departmentDepto. de Biología Celular
dc.description.facultyFac. de Ciencias Biológicas
dc.description.refereedTRUE
dc.description.sponsorshipEuropean Commission
dc.description.sponsorshipMinisterio de Ciencia e Innovación (España)
dc.description.sponsorshipAgencia Estatal de Investigación (España)
dc.description.sponsorshipInstituto de Salud Carlos III (España)
dc.description.statuspub
dc.identifier.citationGarcía-Segura LM, Méndez P, Arevalo MA, Azcoitia I. Neuroestradiol and neuronal development: Not an exclusive male tale anymore. Frontiers in Neuroendocrinology 2023;71:101102. https://doi.org/10.1016/j.yfrne.2023.101102.
dc.identifier.doi10.1016/j.yfrne.2023.101102
dc.identifier.issn0091-3022
dc.identifier.officialurlhttps://doi.org/10.1016/j.yfrne.2023.101102
dc.identifier.relatedurlhttps://www.sciencedirect.com/science/article/pii/S009130222300050X#ab010
dc.identifier.urihttps://hdl.handle.net/20.500.14352/121508
dc.journal.titleFrontiers in Neuroendocrinology
dc.language.isoeng
dc.page.final15
dc.page.initial1
dc.publisherElsevier
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-115019RB-I00/ES/IMPACTO DEL SEXO Y LA EDAD SOBRE LA FUNCION DE LA GLIA EN EL CEREBRO LESIONADO /
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-112824GB-I00/ES/SINTESIS LOCAL DE ESTROGENOS EN NEURONAS INHIBITORIAS DEL HIPOCAMPO: IMPLICACIONES PARA LA FUNCION CEREBRAL Y EFECTOS DEL SEXO/
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu611.018.74
dc.subject.cdu611.013
dc.subject.cdu577.17
dc.subject.keywordAromatase
dc.subject.keywordBrain steroidogenesis
dc.subject.keywordEpigenetic regulation
dc.subject.keywordKdm6a/Utx
dc.subject.keywordNeurogenesis
dc.subject.keywordNeuritogenesis
dc.subject.keywordNeuronal migration
dc.subject.keywordRadial glia
dc.subject.keywordSex-specific effects
dc.subject.keywordSynaptogenesis
dc.subject.ucmNeurociencias (Biológicas)
dc.subject.ucmNeurociencias (Medicina)
dc.subject.ucmFisiología
dc.subject.ucmBiología celular (Biología)
dc.subject.unesco2490.01 Neurofisiología
dc.subject.unesco2490.02 Neuroquímica
dc.subject.unesco2407 Biología Celular
dc.subject.unesco2302.29 Esteroides
dc.titleNeuroestradiol and neuronal development: not an exclusive male tale anymore
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number71
dspace.entity.typePublication
relation.isAuthorOfPublication3f384a95-239e-44bf-a69c-a9ee0dee8f60
relation.isAuthorOfPublication.latestForDiscovery3f384a95-239e-44bf-a69c-a9ee0dee8f60

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