Publication:
Differences in Nutritional Status and Inflammatory Biomarkers between Female and Male Patients with Bronchiectasis: A Large-Cohort Study

dc.contributor.authorWang, Xuejie
dc.contributor.authorVilla, Carmen
dc.contributor.authorDobarganes, Yadira
dc.contributor.authorOlveira, Casilda
dc.contributor.authorGirón, Rosa
dc.contributor.authorGarcía Clemente, Marta
dc.contributor.authorMaíz, Luis
dc.contributor.authorSibila, Oriol
dc.contributor.authorGolpe, Rafael
dc.contributor.authorMenéndez, Rosario
dc.contributor.authorRodríguez López, Juan Pedro
dc.contributor.authorPrados, Concepción
dc.contributor.authorMartinez García, Miguel Angel
dc.contributor.authorRodríguez Hermosa, Juan Luis
dc.contributor.authorde la Rosa, David
dc.contributor.authorDuran, Xavier
dc.contributor.authorBarreiro, Esther
dc.date.accessioned2023-06-16T14:18:58Z
dc.date.available2023-06-16T14:18:58Z
dc.date.issued2021-07-28
dc.description.abstractWe hypothesized that systemic inflammatory and nutritional parameters may differ between male and female patients with non-CF bronchiectasis. In a large patient cohort from the Spanish Online Bronchiectasis Registry (RIBRON), clinical features, systemic inflammatory and nutritional parameters were analyzed in male and female patients with bronchiectasis. Lung function, disease severity using several scores, nutritional status, systemic inflammatory parameters, and multivariate regression analyses were performed to identify differences between male and female patients in the target variables. The number of female patients included in the registry was greater than male patients and they had a less severe disease as measured by all three indices of disease severity, a lower degree of airway obstruction, worse diffusion capacity and airway trapping, better nutritional parameters, and lower levels of inflammatory biomarkers. Multivariate regression analysis evidenced that strong relationships were found between female gender and the following variables: total numbers of leukocytes and neutrophils, hemoglobin, hematocrit, creatinine, and body mass index (BMI). Multivariate regression analyses evidenced that nutritional parameters and inflammatory biomarkers may be reliable indicators of gender-related differences in patients with non-CF bronchiectasis. These findings deserve further attention in follow-up investigations in which the potential predictive value of those biomarkers should be thoroughly explored.
dc.description.departmentDepto. de Medicina
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.sponsorshipInstituto de Salud Carlos III (ISCIII)/FEDER
dc.description.sponsorshipInstituto de Salud Carlos III
dc.description.sponsorshipSEPAR 2020
dc.description.sponsorshipZAMBON-PHARMA
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/69643
dc.identifier.doi10.3390/biomedicines9080905
dc.identifier.issn2227-9059
dc.identifier.officialurlhttps://doi.org/10.3390/biomedicines9080905
dc.identifier.relatedurlhttps://www.mdpi.com/2227-9059/9/8/905
dc.identifier.urihttps://hdl.handle.net/20.500.14352/4649
dc.issue.number8
dc.journal.titleBiomedicines
dc.language.isoeng
dc.page.initial905
dc.publisherMPDI
dc.relation.projectIDFIS 18/00075, FIS 21/00215
dc.relation.projectIDCIBERES
dc.rightsAtribución 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/es/
dc.subject.keywordbronchiectasis
dc.subject.keywordgender-related differences
dc.subject.keywordsystemic inflammation
dc.subject.keywordnutritional status
dc.subject.keywordbiomarkers
dc.subject.keyworddisease severity
dc.subject.ucmGastroenterología y hepatología
dc.subject.ucmNeumología
dc.subject.unesco3205.03 Gastroenterología
dc.subject.unesco3205.08 Enfermedades Pulmonares
dc.titleDifferences in Nutritional Status and Inflammatory Biomarkers between Female and Male Patients with Bronchiectasis: A Large-Cohort Study
dc.typejournal article
dc.volume.number9
dspace.entity.typePublication
relation.isAuthorOfPublication86a02762-7c9f-4535-b728-7ee0fdcefce3
relation.isAuthorOfPublication3337a5ba-7b25-4df3-a451-922ebb41e974
relation.isAuthorOfPublication.latestForDiscovery86a02762-7c9f-4535-b728-7ee0fdcefce3
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