Minimal Residual Disease Monitoring with Next-Generation Sequencing Methodologies in Hematological Malignancies

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dc.contributor.authorSánchez, Ricardo
dc.contributor.authorAyala Díaz, Rosa María
dc.contributor.authorMartínez López, Joaquín
dc.date.accessioned2023-06-17T12:35:33Z
dc.date.available2023-06-17T12:35:33Z
dc.date.issued2019-06-10
dc.description.abstractUltra-deep next-generation sequencing has emerged in recent years as an important diagnostic tool for the detection and follow-up of tumor burden in most of the known hematopoietic malignancies. Meticulous and high-throughput methods for the lowest possible quantified disease are needed to address the deficiencies of more classical techniques. Precision-based approaches will allow us to correctly stratify each patient based on the minimal residual disease (MRD) after a treatment cycle. In this review, we consider the most prominent ways to approach next-generation sequencing methodologies to follow-up MRD in hematological neoplasms.
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/65882
dc.identifier.doi10.3390/ijms20112832
dc.identifier.issn1422-0067
dc.identifier.officialurlhttps://doi.org/10.3390/ijms20112832
dc.identifier.relatedurlhttps://www.mdpi.com/1422-0067/20/11/2832
dc.identifier.urihttps://hdl.handle.net/20.500.14352/12572
dc.issue.number11
dc.journal.titleInternational Journal of Molecular Sciences
dc.language.isoeng
dc.page.initial2832
dc.publisherMDPI
dc.rightsAtribución 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/es/
dc.subject.keywordminimal residual disease
dc.subject.keywordnext-generation sequencing
dc.subject.keywordclonal evolution
dc.subject.keywordhematological neoplasms
dc.subject.keywordhigh-throughput sequencing
dc.subject.ucmOncología
dc.subject.unesco3201.01 Oncología
dc.titleMinimal Residual Disease Monitoring with Next-Generation Sequencing Methodologies in Hematological Malignancies
dc.typejournal article
dc.volume.number20
dspace.entity.typePublication
relation.isAuthorOfPublicatione6f24d0a-7a49-49e1-8482-fd36f9fa1627
relation.isAuthorOfPublication5d58b324-f60e-4598-941b-4a07291634a9
relation.isAuthorOfPublication.latestForDiscoverye6f24d0a-7a49-49e1-8482-fd36f9fa1627
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