Self-immolative polymers as novel pH-responsive gate keepers for drug delivery
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2017
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Gisbert-Garzaran M, Lozano D, Vallet-Regí M, Manzano M. Self-immolative polymers as novel pH-responsive gate keepers for drug delivery. RSC Adv 2017;7:132–6. https://doi.org/10.1039/C6RA26771H.
Abstract
A novel pH-sensitive nanocarrier based on mesoporous silica nanoparticles with self-immolative polymers blocking the pore openings is presented. Triggered release by acid pH is demonstrated, together with their in vitro biocompatibility and effective cell internalisation, which makes this new material a promising candidate for future applications in cancer treatment.