Refractive index tomography for drug-induced liver injury analysis

Soto Rueda, Juan Manuel; Aguilar Mora, Fabio; Rodrigo Martín-Romo, José Augusto; Geng, Yana; Musheshe, Nshunge; Buist-Homan, Manon; Lezoualc’h, Frank; Cheng, Xiaodong; Schmidt, Martina; Moshage, Han; Alieva Krasheninnikova, Tatiana

Refractive index tomography for drug-induced liver injury analysis

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Official URL

http://dx.doi.org/10.1117/12.2615732

Publication date

2021

Authors

Soto Rueda, Juan Manuel

Aguilar Mora, Fabio

Rodrigo Martín-Romo, José Augusto

Publisher

Society of Photo-Optical Instrumentation Engineers (SPIE)

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URI

https://hdl.handle.net/20.500.14352/4922

Abstract

Refractive index tomography compatible with conventional microscope is used for analyzing primary rat hepatocytes injury induced by pharmacological treatments. We found that mitochondria malfunctioning is correlated with refractive index variations.

Description

© (2021) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). ISBN: 978-1-5106-4711-4; 978-1-5106-4710-7. European Conferences on Biomedical Optics. Advances in Microscopic Imaging (3.2021). The authors acknowledge Spanish Ministerio de Ciencia y Universidades for funding the project PGC2018-095595- B-I0.