Addressing catheter lock therapy: Does heparin reduce the bioactivity of dalbavancin when together in solution during freezing?
Loading...
Official URL
Full text at PDC
Publication date
2024
Advisors (or tutors)
Editors
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Citations
Exportar
Citation
Díaz-Navarro, M., Hafian, R., Pérez-Granda, M. J., Cercenado, E., Muñoz, P., & Guembe, M. (2024). Addressing catheter lock therapy: Does heparin reduce the bioactivity of dalbavancin when together in solution during freezing? Enfermedades Infecciosas y Microbiologia Clinica (English Ed.), 42(8), 435-438. https://doi.org/10.1016/j.eimce.2024.02.013
Abstract
Introduction: The possible use of dalbavancin as a catheter lock solution was previously demonstrated by our study group. However, it was needed to assess whether heparin could affect dalbavancin bioactivity during freezing storage.
Methods: We tested the bioactivity of a dalbavancin+heparin (DH) vs. dalbavancin (D) against Staphylococcal biofilms comparing DH median value of cfu counts and metabolic activity with that obtained for D before and during storage under freezing up to 6 months.
Results: Despite there was a slight decrease in the median percentage reduction of metabolic activity at month 3 in Staphylococcus epidermidis between DH and D (97.6 vs. 100, p=0.037), considering the clinical criteria, no significant reduction in any of the variables tested was observed at the end of the experiment between D and DH solutions.
Conclusion: The addition of heparin to a dalbavancin lock solution did not affect its bioactivity against staphylococcal biofilms irrespective of its preservation time under freezing.
Keywords: Bioactividad; Bioactivity; Biofilms; Biopelículas; Congelación; Dalbavancin; Dalbavancina; Freezing; Heparin; Heparina; Lock therapy; Terapia de sellado.
Description
M. Guembe is supported by the Miguel Servet Program (ISCIII-MICINN, MS18/00008) of the Health Research Fund (FIS) of the Carlos III Health Institute (ISCIII), Madrid, Spain. M. Díaz-Navarro is supported by ISCIII (FI22/00022). The study was partially financed by grants from the ISCIII (PI21/00344), the Fundación Mutua Madrileña (FMM21/01), IiSGM (2022-PI-II-COOPTR-01), and the European Regional Development Fund (FEDER) “A way of making Europe”.