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Antimicrobial susceptibilities of Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis strains from periodontitis patients in Morocco

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dc.contributor.authorMínguez, M.
dc.contributor.authorEnnibi, O. K.
dc.contributor.authorPerdiguero Jiménez, Pedro
dc.contributor.authorLakhdar, L.
dc.contributor.authorAbdellaoui, L.
dc.contributor.authorSánchez Beltrán, María Del Carmen
dc.contributor.authorSanz Alonso, Mariano
dc.contributor.authorHerrera González, David
dc.date.accessioned2024-10-14T17:05:12Z
dc.date.available2024-10-14T17:05:12Z
dc.date.issued2019-03-08
dc.description.abstractBackground and objective: Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis have been frequently isolated in periodontitis patients in Morocco. Its persistence after the subgingival debridement of the biofilm has been correlated with worse clinical outcomes. The aim of this study was to evaluate the antimicrobial susceptibilities of A. actinomycetemcomitans and P. gingivalis, to amoxicillin, amoxicillin plus clavulanate, metronidazole, and azithromycin. In addition, microbiological profiles of patients harbouring A. actinomycetemcomitans, P. gingivalis, or both were compared. Material and methods: In 45 consecutive periodontitis Moroccan patients, subgingival samples were taken and processed by culture. Twenty-four A. actinomycetemcomitans and 30 P. gingivalis colonies were isolated (54 strains) and susceptibility tests, using the epsilometric method, were run for amoxicillin, amoxicillin plus clavulanate, metronidazole, and azithromycin. Minimum inhibitory concentrations for 50 (MIC50) and 90% (MIC90) of the organisms were calculated. Results: The prevalence of A. actinomycetemcomitans and P. gingivalis was 79.5 and 84.4%, respectively. A. actinomycetemcomitans showed susceptibility to amoxicillin, amoxicillin plus clavulanate, while 28% of the isolated strains were resistant to azithromycin and 61.7% towards metronidazole. No P. gingivalis resistance towards amoxicillin, amoxicillin plus clavulanate, metronidazole, and azithromycin was found. Conclusion: A. actinomycetemcomitans and P. gingivalis were frequently detected in Moroccan patients with periodontitis, while antimicrobial resistance was only detected for A. actinomycetemcomitans to metronidazole and azithromycin. Clinical relevance: A. actinomycetemcomitans resistance against some antimicrobials in periodontitis patients in Morocco can influence the selection of the therapeutic approaches.en
dc.description.departmentDepto. de Especialidades Clínicas Odontológicas
dc.description.facultyFac. de Odontología
dc.description.refereedTRUE
dc.description.sponsorshipUniversidad Complutense de Madrid (España)
dc.description.sponsorshipEtiología y terapéutica de enfermedades periodontales y periimplantarias
dc.description.statuspub
dc.identifier.citationMínguez M, Ennibi OK, Perdiguero P, Lakhdar L, Abdellaoui L, Sánchez MC, Sanz M, Herrera D. Antimicrobial susceptibilities of Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis strains from periodontitis patients in Morocco. Clin Oral Investig. 2019 Mar;23(3):1161-1170. doi: 10.1007/s00784-018-2539-2
dc.identifier.doi10.1007/s00784-018-2539-2
dc.identifier.essn1436-3771
dc.identifier.issn1432-6981
dc.identifier.officialurlhttps://doi.org/10.1007/s00784-018-2539-2
dc.identifier.pmid29967975
dc.identifier.relatedurlhttps://link.springer.com/article/10.1007/s00784-018-2539-2
dc.identifier.relatedurlhttps://pubmed.ncbi.nlm.nih.gov/29967975/
dc.identifier.urihttps://hdl.handle.net/20.500.14352/108960
dc.issue.number3
dc.journal.titleClinical Oral Investigations
dc.language.isoeng
dc.page.final1170
dc.page.initial1161
dc.publisherSpringer
dc.rights.accessRightsrestricted access
dc.subject.cdu579.61
dc.subject.cdu616.314.17-008.1
dc.subject.keywordAntimicrobial susceptibilities
dc.subject.keywordPeriodontitis
dc.subject.keywordMorocco
dc.subject.keywordAggregatibacter actinomycetemcomitans
dc.subject.keywordPorphyromonas gingivalis
dc.subject.ucmCiencias Biomédicas
dc.subject.ucmOdontología (Odontología)
dc.subject.ucmPeriodoncia
dc.subject.ucmMicrobiología médica
dc.subject.unesco32 Ciencias Médicas
dc.subject.unesco3213.13 Ortodoncia-Estomatología
dc.subject.unesco3201.03 Microbiología Clínica
dc.subject.unesco5102.05 Hábitat
dc.titleAntimicrobial susceptibilities of Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis strains from periodontitis patients in Moroccoen
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number23
dspace.entity.typePublication
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relation.isAuthorOfPublication27fce85c-05b6-4420-b0a4-22ef8510f4e2
relation.isAuthorOfPublication64cb103c-84c2-43c3-a4fc-60b1e598007d
relation.isAuthorOfPublication92a06fae-e947-48dc-b945-32283225e711
relation.isAuthorOfPublication.latestForDiscovery79d96b75-77f0-4b4c-8fc8-94094fe6d041

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