Chitosan-Based Composite Membranes with Different Biocompatible Metal Oxide Nanoparticles: Physicochemical Properties and Drug-Release Study
Loading...
Official URL
Full text at PDC
Publication date
2023
Advisors (or tutors)
Editors
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI
Citation
Baroudi, A.; García-Payo, C.; Khayet, M. Chitosan-Based Composite Membranes with Different Biocompatible Metal Oxide Nanoparticles: Physicochemical Properties and Drug-Release Study. Polymers 2023, 15, 2804. https://doi.org/10.3390/polym15132804
Abstract
Chitosan (CS) composite membranes were prepared using different biocompatible metal oxide nanoparticles (NPs): titanium dioxide (TiO2); iron oxide (Fe3O4); and aluminum oxide (Al2O3). For each nanoparticle, the CS-based composite membranes were prepared with two NPs contents in the CS solution, high (H) and low (L) NPs concentrations. To establish both concentrations, the NPs
saturation point in the CS polymeric matrix was determined. The influence of NP concentrations on the physicochemical properties of the CS films was assessed. The prepared CS membranes were
characterized with different techniques, such as X-ray diffraction (XRD), scanning electron microscopy (SEM), and zeta potential. It was found that the addition of NPs in the CS matrix improved both
swelling and mechanical properties. Nanocomposite CS membranes could be prepared using Al2O3 NPs. Swelling experiments revealed different pH-sensitive mechanisms, which might be beneficial
in biomedical applications since solute permeation through CS-based composite membranes could be controlled by adjusting environmental conditions. When aspirin transport (ASA) through the
prepared membranes was carried out in different release media, SGF (simulating gastric fluid) and SIF (simulating intestinal fluid without enzymes), it was observed that the Fickian diffusion coefficient
(D) was conditioned by the pH of the release solution. In SGIT (simulating gastrointestinal transit) medium, a transition time (ttrans) was detected due to the shrinkage of the CS polymeric chains,
and the drug release depended not only on the Fickian’s diffusion but also on the shrinkage of the biopolymer, obeying Peppas and Sahlin equation.
Description
2023 Descuento MDPI