Ingeniería de biocatalizadores enzimáticos para la intensificación de bioprocesos oxidativos
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2024
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11/07/2024
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Universidad Complutense de Madrid
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Abstract
Las transformaciones químicas basadas en procesos enzimáticos han ganado una enorme relevancia en los últimos años en el contexto del desarrollo sostenible. Las suaves condiciones de reacción necesarias unidas a la considerable reducción de subproductos y la baja toxicidad de los disolventes empleados y la eficiencia catalítica con exquisita selectividad han situado a la biocatálisis como referencia de futuro y sostenibilidad. Dentro de la biocatálisis, las oxidasas son un grupo de enzimas muy atractivas por su capacidad para oxidar una amplia variedad de sustratos. Su potencial aplicación en campos como la remediación de contaminantes, la industria farmacéutica o la producción de compuestos de interés en biorrefinerías las ha convertido en claros objetivos de desarrollo en ingeniería de proteínas y bioprocesos. Sin embargo, su aplicación está fuertemente limitada por la baja solubilidad del O2 en medio acuoso, siendo necesario un aporte continuado de éste durante la reacción...
Chemical transformations based on enzymatic processes have gained enormous relevance in recent years due to their greater respect for the environment. The mild reaction conditions required, together with the considerable reduction of by-products and the low toxicity of the solvents used, have positioned biocatalysis as a reference for the future and sustainability.Within biocatalysis, oxidases are a very attractive group of enzymes due to their ability to oxidize a wide variety of substrates. Their potential application in fields such as pollutant remediation, the pharmaceutical industry, or the production of compounds of interest in biorefineries has made them clear targets for development in protein engineering and bioprocesses. However, their application is strongly limited by the low solubility of O2 in aqueous media, requiring a continuous supply of O2 during the reaction...
Chemical transformations based on enzymatic processes have gained enormous relevance in recent years due to their greater respect for the environment. The mild reaction conditions required, together with the considerable reduction of by-products and the low toxicity of the solvents used, have positioned biocatalysis as a reference for the future and sustainability.Within biocatalysis, oxidases are a very attractive group of enzymes due to their ability to oxidize a wide variety of substrates. Their potential application in fields such as pollutant remediation, the pharmaceutical industry, or the production of compounds of interest in biorefineries has made them clear targets for development in protein engineering and bioprocesses. However, their application is strongly limited by the low solubility of O2 in aqueous media, requiring a continuous supply of O2 during the reaction...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Ciencias Químicas, leída el 11-07-2024