Sonic Hedgehog signaling in oligodendrogenesis, myelination, demyelinating diseases, and remyelination

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dc.contributor.authorMarchena-Fernández, Miguel
dc.contributor.authorSánchez-Camacho Blázquez, Cristina
dc.contributor.authorMuñoz-Sáez, Emma
dc.contributor.authorMacías-Castellano, Alba
dc.contributor.authorCastro Soubriet, Fernando de
dc.date.accessioned2025-10-22T15:33:08Z
dc.date.available2025-10-22T15:33:08Z
dc.date.issued2025-08-13
dc.descriptionSupported by the Spanish Government (PID2022-143110OB-IOO), Merck Foundation (20234599), and Universidad Camilo José Cela (CEIDI_VI_08_06_XI_EMYDEM).
dc.description.abstractThe Hedgehog (HH) family includes Indian (IHH), Desert (DHH), and Sonic Hedgehog (SHH). HH signaling plays a crucial role in myelination and oligodendrocyte lineage development. SHH regulates the specification, proliferation, and migration of oligodendrocyte precursor cells (OPCs), being essential for myelin production and remyelination. The balance of SHH/SMO signaling affects both oligodendrocyte differentiation and demyelinating disease progression. Understanding this pathway may open new therapeutic strategies for multiple sclerosis and leukodystrophies.
dc.description.departmentDepto. de Genética, Fisiología y Microbiología
dc.description.facultyFac. de Ciencias Biológicas
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Ciencia e Innovación (España)
dc.description.sponsorshipMerck Foundation (Reino Unido)
dc.description.sponsorshipUniversidad Camilo José Cela (España)
dc.description.statuspub
dc.identifier.citationMarchena-Fernández M, Sánchez-Camacho C, Muñoz-Sáez E, Macías-Castellano A, de Castro Soubriet F (2026). Sonic Hedgehog signaling in oligodendrogenesis, myelination, demyelinating diseases, and remyelination. Neural Regen Res. https://doi.org/10.4103/NRR.NRR-D-25-00005
dc.identifier.doi10.4103/nrr.nrr-d-25-00005
dc.identifier.essn1876-7958
dc.identifier.issn1673-5374
dc.identifier.officialurlhttps://doi.org/10.4103/nrr.nrr-d-25-00005
dc.identifier.urihttps://hdl.handle.net/20.500.14352/125270
dc.journal.titleNeural Regeneration Research
dc.language.isoeng
dc.publisherWolters Kluwer Medknow Publications
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-143110OB-I00/ES/(RE)MIELINIZACION EN ESCLEROSIS MULTIPLE Y LEUCODISTROFIAS DESMIELINIZANTES RARAS: DESARROLLO DE MODELOS DE ENFERMEDAD IN VITRO E IN VIVO PARA CONSEGUIR PRODUCIR MIELINA/
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu612.82
dc.subject.ucmNeurociencias (Biológicas)
dc.subject.ucmFisiología animal (Biología)
dc.subject.ucmBiología celular (Biología)
dc.subject.unesco2407.04 Citología
dc.subject.unesco2411.11 Neurofisiología
dc.subject.unesco2490 Neurociencias
dc.subject.unesco3205.07 Neurología
dc.titleSonic Hedgehog signaling in oligodendrogenesis, myelination, demyelinating diseases, and remyelination
dc.typejournal article
dc.type.hasVersionVoR
dspace.entity.typePublication
relation.isAuthorOfPublication2ce1597c-df9d-46cd-b799-7b421378ee34
relation.isAuthorOfPublication.latestForDiscovery2ce1597c-df9d-46cd-b799-7b421378ee34

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