Sonic Hedgehog signaling in oligodendrogenesis, myelination, demyelinating diseases, and remyelination
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2025
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Wolters Kluwer Medknow Publications
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Marchena-Fernández M, Sánchez-Camacho C, Muñoz-Sáez E, Macías-Castellano A, de Castro Soubriet F (2026). Sonic Hedgehog signaling in oligodendrogenesis, myelination, demyelinating diseases, and remyelination. Neural Regen Res. https://doi.org/10.4103/NRR.NRR-D-25-00005
Abstract
The Hedgehog (HH) family includes Indian (IHH), Desert (DHH), and Sonic Hedgehog (SHH). HH signaling plays a crucial role in myelination and oligodendrocyte lineage development. SHH regulates the specification, proliferation, and migration of oligodendrocyte precursor cells (OPCs), being essential for myelin production and remyelination. The balance of SHH/SMO signaling affects both oligodendrocyte differentiation and demyelinating disease progression. Understanding this pathway may open new therapeutic strategies for multiple sclerosis and leukodystrophies.
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Supported by the Spanish Government (PID2022-143110OB-IOO), Merck Foundation (20234599), and Universidad Camilo José Cela (CEIDI_VI_08_06_XI_EMYDEM).