TRIB3 suppresses tumorigenesis by controlling mTORC2/AKT/FOXO signaling

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dc.contributor.authorSalazar Roa, María
dc.contributor.authorLorente Pérez, María Del Mar
dc.contributor.authorGarcía Taboada, Elena
dc.contributor.authorGómez, Eduardo P.
dc.contributor.authorDávila, David
dc.contributor.authorZúñiga García, Patricia
dc.contributor.authorFlores Landeira, Juana María
dc.contributor.authorRodríguez, Antonio
dc.contributor.authorHegedus, Zoltan
dc.contributor.authorMosen Ansorena, David
dc.contributor.authorAransay, Ana M.
dc.contributor.authorHernandez Tiedra, Sonia
dc.contributor.authorLópez Valero, Israel
dc.contributor.authorQuintanilla, Miguel
dc.contributor.authorSánchez García, María Cristina
dc.contributor.authorIovanna, Juan L
dc.contributor.authorDusetti, Nelson
dc.contributor.authorGuzmán Pastor, Manuel
dc.contributor.authorFrancis, Sheila E.
dc.contributor.authorCarracedo, Arkaitz
dc.contributor.authorKiss-Toth, Endre
dc.contributor.authorVelasco Díez, Guillermo
dc.date.accessioned2025-11-05T13:01:48Z
dc.date.available2025-11-05T13:01:48Z
dc.date.issued2015-04
dc.description.abstractIn a recent article, we found that Tribbles pseudokinase 3 (TRIB3) plays a tumor suppressor role and that this effect relies on the dysregulation of the phosphorylation of v-akt murine thymoma viral oncogene homolog (AKT) by the mammalian target of rapamycin complex 2 (mTORC2 complex), and the subsequent hyperphosphorylation and inactivation of the transcription factor Forkhead box O3 (FOXO3).
dc.description.departmentDepto. de Bioquímica y Biología Molecular
dc.description.departmentDepto. de Medicina y Cirugía Animal
dc.description.facultyFac. de Ciencias Biológicas
dc.description.facultyFac. de Ciencias Químicas
dc.description.facultyFac. de Veterinaria
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.citationSalazar, M., Lorente, M., García-Taboada, E., Gómez, E. P., Dávila, D., Zúñiga-García, P., … Velasco, G. (2015). TRIB3 suppresses tumorigenesis by controlling mTORC2/AKT/FOXO signaling. Molecular & Cellular Oncology, 2(3). https://doi.org/10.4161/23723556.2014.980134
dc.identifier.doi10.4161/23723556.2014.980134
dc.identifier.essn2372-3556
dc.identifier.officialurlhttp://dx.doi.org/10.4161/23723556.2014.980134
dc.identifier.relatedurlhttps://www.tandfonline.com/doi/10.4161/23723556.2014.980134?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
dc.identifier.urihttps://hdl.handle.net/20.500.14352/125762
dc.issue.number3
dc.journal.titleMolecular & Cellular Oncology
dc.language.isoeng
dc.page.final3
dc.page.initial1
dc.publisherTaylor and Francis
dc.rightsAttribution-NonCommercial 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subject.cdu577.2
dc.subject.cdu576
dc.subject.cdu616-006.04
dc.subject.keywordTribbles pseudokinases
dc.subject.keywordAnimal models of cancer
dc.subject.keywordSkin carcinogenesis
dc.subject.keywordPTEN
dc.subject.keywordProstate cancer
dc.subject.ucmBiología molecular (Biología)
dc.subject.ucmBiología celular (Biología)
dc.subject.ucmOncología
dc.subject.unesco2415 Biología Molecular
dc.subject.unesco2407 Biología Celular
dc.subject.unesco3201.01 Oncología
dc.titleTRIB3 suppresses tumorigenesis by controlling mTORC2/AKT/FOXO signaling
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number2
dspace.entity.typePublication
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