TRIB3 suppresses tumorigenesis by controlling mTORC2/AKT/FOXO signaling
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2015
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Taylor and Francis
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Salazar, M., Lorente, M., García-Taboada, E., Gómez, E. P., Dávila, D., Zúñiga-García, P., … Velasco, G. (2015). TRIB3 suppresses tumorigenesis by controlling mTORC2/AKT/FOXO signaling. Molecular & Cellular Oncology, 2(3). https://doi.org/10.4161/23723556.2014.980134
Abstract
In a recent article, we found that Tribbles pseudokinase 3 (TRIB3) plays a tumor suppressor role and that this effect relies on the dysregulation of the phosphorylation of v-akt murine thymoma viral oncogene homolog (AKT) by the mammalian target of rapamycin complex 2 (mTORC2 complex), and the subsequent hyperphosphorylation and inactivation of the transcription factor Forkhead box O3 (FOXO3).