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Silicon alleviates nonalcoholic steatohepatitis by reducing apoptosis in aged wistar rats fed a high-saturated fat, high-cholesterol diet

dc.contributor.authorGarcimartín Álvarez, Alba
dc.contributor.authorLópez-Oliva Muñoz, María Elvira
dc.contributor.authorSantos López, Jorge Arturo
dc.contributor.authorGarcía Fernández, Rosa Ana
dc.contributor.authorMacho González, Adrián
dc.contributor.authorBastida Codina, Sara
dc.contributor.authorBenedí González, Juana María
dc.contributor.authorSánchez Muniz, Francisco José
dc.date.accessioned2024-11-05T16:49:01Z
dc.date.available2024-11-05T16:49:01Z
dc.date.issued2017
dc.descriptionAcknowledgments: We thank the Centro de Experimentacion Animal of the Alcal ´ a´ University, Madrid, Spain, for feeding and caring for the rats. The authors responsibilities were as follows—AG, MEL-O, and FJS-M: designed the research; AG, MEL-O, JAS-L, AM-G, and RAG-F: conducted the research; AG, MEL-O, SB, and JB: analyzed the data; AG, MEL-O, SB, JB, and FJS-M: wrote the paper; FJS-M: had primary responsibility for the final content; and all authors: read and approved the final manuscript Experimental design The study was approved by the Spanish Science and Technology Advisory Committee (project AGL2011-29644-C02-02) and by an ethics committee at the Universidad Complutense of Madrid (Spain).
dc.description.abstractSilicon included in a restructured meat (RM) matrix (Si-RM) as a functional ingredient has been demonstrated to be a potential bioactive antidiabetic compound. However, the jejunal and hepatic molecular mechanisms by which Si-RM exerts its cholesterol-lowering effects remain unclear. Male Wistar rats fed an RM included in a high-saturated-fat high-cholesterol diet (HSFHCD) combined with a low dose of streptozotocin plus nicotinamide injection were used as late-stage type 2 diabetes mellitus (T2DM) model. Si-RM was included into the HSFHCD as a functional food. An early-stage TD2M group fed a high-saturated-fat diet (HSFD) was taken as reference. Si-RM inhibited the hepatic and intestinal microsomal triglyceride transfer protein (MTP) reducing the apoB-containing lipoprotein assembly and cholesterol absorption. Upregulation of liver X receptor (LXRα/β) by Si-RM turned in a higher low-density lipoprotein receptor (LDLr) and ATP-binding cassette transporters (ABCG5/8, ABCA1) promoting jejunal cholesterol efflux and transintestinal cholesterol excretion (TICE), and facilitating partially reverse cholesterol transport (RCT). Si-RM decreased the jejunal absorptive area and improved mucosal barrier integrity. Consequently, plasma triglycerides and cholesterol levels decreased, as well as the formation of atherogenic lipoprotein particles. Si-RM mitigated the dyslipidemia associated with late-stage T2DM by Improving cholesterol homeostasis. Silicon could be used as an effective nutritional approach in diabetic dyslipidemia management.
dc.description.departmentDepto. de Farmacología, Farmacognosia y Botánica
dc.description.departmentSección Deptal. de Fisiología (Farmacia)
dc.description.departmentDepto. de Medicina y Cirugía Animal
dc.description.departmentDepto. de Nutrición y Ciencia de los Alimentos
dc.description.facultyFac. de Farmacia
dc.description.facultyFac. de Veterinaria
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Economía, Comercio y Empresa ( España)
dc.description.sponsorshipSantander- Universidad Complutense de Madrid
dc.description.statuspub
dc.identifier.citationHernández-Martín, M., Garcimartín, A., Bocanegra, A., Redondo-Castillejo, R., Quevedo-Torremocha, C., Macho-González, A., García Fernández, R. A., Bastida, S., Benedí, J., Sánchez-Muniz, F. J., & López-Oliva, M. E. (2024). Silicon as a Functional Meat Ingredient Improves Jejunal and Hepatic Cholesterol Homeostasis in a Late-Stage Type 2 Diabetes Mellitus Rat Model. Foods, 13(12). https://doi.org/10.3390/FOODS13121794
dc.identifier.doi10.3945/jn.116.243204
dc.identifier.issn2304-8158
dc.identifier.officialurlhttps://www.sciencedirect.com/science/article/pii/S0022316622107649?via%3Dihub
dc.identifier.pmid28446627
dc.identifier.urihttps://hdl.handle.net/20.500.14352/110030
dc.issue.number6
dc.journal.titleJournal of Nutrition
dc.language.isoeng
dc.page.final1112
dc.page.initial1104
dc.publisherASN
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//AGL2014-53207-C2-2-R/ES/EFECTOS DEL CONSUMO DE CARNICOS CON PERFIL GRASO OPTIMIZADO CONTENIENDO TANINOS ALTAMENTE CONDENSADOS SOBRE LAS COMPLICACIONES FISIOMETABOLICAS ASOCIADAS A DIABETES MELLITUS 2/
dc.relation.projectIDPR75/18-21603
dc.relation.projectIDPID2019-103872RB-I00
dc.relation.projectIDMCIN/AEI/10.13039/501 100 011 033
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu613.2
dc.subject.keywordWistar ratsaging
dc.subject.keywordAging
dc.subject.keywordSi-enriched restructured pork
dc.subject.keywordNAFLD
dc.subject.keywordNASH
dc.subject.keywordLipoapoptosis
dc.subject.ucmDietética y nutrición (Farmacia)
dc.subject.ucmBioquímica (Farmacia)
dc.subject.unesco3206 Ciencias de la Nutrición
dc.titleSilicon alleviates nonalcoholic steatohepatitis by reducing apoptosis in aged wistar rats fed a high-saturated fat, high-cholesterol diet
dc.typejournal article
dc.type.hasVersionAM
dc.volume.number146
dspace.entity.typePublication
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