Silicon alleviates nonalcoholic steatohepatitis by reducing apoptosis in aged wistar rats fed a high-saturated fat, high-cholesterol diet
dc.contributor.author | Garcimartín Álvarez, Alba | |
dc.contributor.author | López-Oliva Muñoz, María Elvira | |
dc.contributor.author | Santos López, Jorge Arturo | |
dc.contributor.author | García Fernández, Rosa Ana | |
dc.contributor.author | Macho González, Adrián | |
dc.contributor.author | Bastida Codina, Sara | |
dc.contributor.author | Benedí González, Juana María | |
dc.contributor.author | Sánchez Muniz, Francisco José | |
dc.date.accessioned | 2024-11-05T16:49:01Z | |
dc.date.available | 2024-11-05T16:49:01Z | |
dc.date.issued | 2017 | |
dc.description | Acknowledgments: We thank the Centro de Experimentacion Animal of the Alcal ´ a´ University, Madrid, Spain, for feeding and caring for the rats. The authors responsibilities were as follows—AG, MEL-O, and FJS-M: designed the research; AG, MEL-O, JAS-L, AM-G, and RAG-F: conducted the research; AG, MEL-O, SB, and JB: analyzed the data; AG, MEL-O, SB, JB, and FJS-M: wrote the paper; FJS-M: had primary responsibility for the final content; and all authors: read and approved the final manuscript Experimental design The study was approved by the Spanish Science and Technology Advisory Committee (project AGL2011-29644-C02-02) and by an ethics committee at the Universidad Complutense of Madrid (Spain). | |
dc.description.abstract | Silicon included in a restructured meat (RM) matrix (Si-RM) as a functional ingredient has been demonstrated to be a potential bioactive antidiabetic compound. However, the jejunal and hepatic molecular mechanisms by which Si-RM exerts its cholesterol-lowering effects remain unclear. Male Wistar rats fed an RM included in a high-saturated-fat high-cholesterol diet (HSFHCD) combined with a low dose of streptozotocin plus nicotinamide injection were used as late-stage type 2 diabetes mellitus (T2DM) model. Si-RM was included into the HSFHCD as a functional food. An early-stage TD2M group fed a high-saturated-fat diet (HSFD) was taken as reference. Si-RM inhibited the hepatic and intestinal microsomal triglyceride transfer protein (MTP) reducing the apoB-containing lipoprotein assembly and cholesterol absorption. Upregulation of liver X receptor (LXRα/β) by Si-RM turned in a higher low-density lipoprotein receptor (LDLr) and ATP-binding cassette transporters (ABCG5/8, ABCA1) promoting jejunal cholesterol efflux and transintestinal cholesterol excretion (TICE), and facilitating partially reverse cholesterol transport (RCT). Si-RM decreased the jejunal absorptive area and improved mucosal barrier integrity. Consequently, plasma triglycerides and cholesterol levels decreased, as well as the formation of atherogenic lipoprotein particles. Si-RM mitigated the dyslipidemia associated with late-stage T2DM by Improving cholesterol homeostasis. Silicon could be used as an effective nutritional approach in diabetic dyslipidemia management. | |
dc.description.department | Depto. de Farmacología, Farmacognosia y Botánica | |
dc.description.department | Sección Deptal. de Fisiología (Farmacia) | |
dc.description.department | Depto. de Medicina y Cirugía Animal | |
dc.description.department | Depto. de Nutrición y Ciencia de los Alimentos | |
dc.description.faculty | Fac. de Farmacia | |
dc.description.faculty | Fac. de Veterinaria | |
dc.description.refereed | TRUE | |
dc.description.sponsorship | Ministerio de Economía, Comercio y Empresa ( España) | |
dc.description.sponsorship | Santander- Universidad Complutense de Madrid | |
dc.description.status | pub | |
dc.identifier.citation | Hernández-Martín, M., Garcimartín, A., Bocanegra, A., Redondo-Castillejo, R., Quevedo-Torremocha, C., Macho-González, A., García Fernández, R. A., Bastida, S., Benedí, J., Sánchez-Muniz, F. J., & López-Oliva, M. E. (2024). Silicon as a Functional Meat Ingredient Improves Jejunal and Hepatic Cholesterol Homeostasis in a Late-Stage Type 2 Diabetes Mellitus Rat Model. Foods, 13(12). https://doi.org/10.3390/FOODS13121794 | |
dc.identifier.doi | 10.3945/jn.116.243204 | |
dc.identifier.issn | 2304-8158 | |
dc.identifier.officialurl | https://www.sciencedirect.com/science/article/pii/S0022316622107649?via%3Dihub | |
dc.identifier.pmid | 28446627 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14352/110030 | |
dc.issue.number | 6 | |
dc.journal.title | Journal of Nutrition | |
dc.language.iso | eng | |
dc.page.final | 1112 | |
dc.page.initial | 1104 | |
dc.publisher | ASN | |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//AGL2014-53207-C2-2-R/ES/EFECTOS DEL CONSUMO DE CARNICOS CON PERFIL GRASO OPTIMIZADO CONTENIENDO TANINOS ALTAMENTE CONDENSADOS SOBRE LAS COMPLICACIONES FISIOMETABOLICAS ASOCIADAS A DIABETES MELLITUS 2/ | |
dc.relation.projectID | PR75/18-21603 | |
dc.relation.projectID | PID2019-103872RB-I00 | |
dc.relation.projectID | MCIN/AEI/10.13039/501 100 011 033 | |
dc.rights | Attribution 4.0 International | en |
dc.rights.accessRights | open access | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject.cdu | 613.2 | |
dc.subject.keyword | Wistar ratsaging | |
dc.subject.keyword | Aging | |
dc.subject.keyword | Si-enriched restructured pork | |
dc.subject.keyword | NAFLD | |
dc.subject.keyword | NASH | |
dc.subject.keyword | Lipoapoptosis | |
dc.subject.ucm | Dietética y nutrición (Farmacia) | |
dc.subject.ucm | Bioquímica (Farmacia) | |
dc.subject.unesco | 3206 Ciencias de la Nutrición | |
dc.title | Silicon alleviates nonalcoholic steatohepatitis by reducing apoptosis in aged wistar rats fed a high-saturated fat, high-cholesterol diet | |
dc.type | journal article | |
dc.type.hasVersion | AM | |
dc.volume.number | 146 | |
dspace.entity.type | Publication | |
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