Specific IgA, But Not IgG, in Human Milk From COVID-19-Infected Mothers Neutralizes SARS-CoV-2
Loading...
Official URL
Full text at PDC
Publication date
2024
Advisors (or tutors)
Editors
Journal Title
Journal ISSN
Volume Title
Publisher
Wolters Kluwer Health
Citations
Exportar
Citation
Macchiaverni, Patricia PhD*,†; Lloyd, Megan PhD*,†,‡; Masters, Laura PhD‡; Divakara, Nivedithaa MS*,†; Panta, Kritu PhD‡; Imrie, Allison PhD‡; Sánchez-García, Laura MD§; Pellicer, Adelina PhD§; Rodriguez, Juan M. MD, PhD¶; Verhasselt, Valerie MD, PhD*,†. Specific IgA, But Not IgG, in Human Milk From COVID-19-Infected Mothers Neutralizes SARS-CoV-2. The Pediatric Infectious Disease Journal 43(6):p 532-535, June 2024. DOI: 10.1097/INF.0000000000004291
Abstract
This study highlights the importance of human milk in providing anti-severe acute respiratory syndrome coronavirus 2 immunity to newborns. The highest protective activity of human milk against COVID-19 was found in colostrum from infected mothers. Neutralizing activity was associated with high levels of specific IgA. Depletion of IgA, but not IgG, from milk samples completely abolished the ability of human milk to neutralize severe acute respiratory syndrome coronavirus 2.