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Specific IgA, But Not IgG, in Human Milk From COVID-19-Infected Mothers Neutralizes SARS-CoV-2

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dc.contributor.authorMacchiaverni, Patricia
dc.contributor.authorLloyd, Megan
dc.contributor.authorMasters, Laura
dc.contributor.authorDivakara, Nivedithaa
dc.contributor.authorPanta, Kritu
dc.contributor.authorImrie, Allison
dc.contributor.authorSánchez García, Laura
dc.contributor.authorPellicer, Adelina
dc.contributor.authorRodríguez Gómez, Juan Miguel
dc.contributor.authorVerhasselt, Valerie
dc.date.accessioned2024-06-26T14:47:27Z
dc.date.available2024-06-26T14:47:27Z
dc.date.issued2024-06-01
dc.description.abstractThis study highlights the importance of human milk in providing anti-severe acute respiratory syndrome coronavirus 2 immunity to newborns. The highest protective activity of human milk against COVID-19 was found in colostrum from infected mothers. Neutralizing activity was associated with high levels of specific IgA. Depletion of IgA, but not IgG, from milk samples completely abolished the ability of human milk to neutralize severe acute respiratory syndrome coronavirus 2.
dc.description.departmentDepto. de Nutrición y Ciencia de los Alimentos
dc.description.facultyFac. de Veterinaria
dc.description.refereedTRUE
dc.description.sponsorshipInstituto de Salud Carlos III
dc.description.statuspub
dc.identifier.citationMacchiaverni, Patricia PhD*,†; Lloyd, Megan PhD*,†,‡; Masters, Laura PhD‡; Divakara, Nivedithaa MS*,†; Panta, Kritu PhD‡; Imrie, Allison PhD‡; Sánchez-García, Laura MD§; Pellicer, Adelina PhD§; Rodriguez, Juan M. MD, PhD¶; Verhasselt, Valerie MD, PhD*,†. Specific IgA, But Not IgG, in Human Milk From COVID-19-Infected Mothers Neutralizes SARS-CoV-2. The Pediatric Infectious Disease Journal 43(6):p 532-535, June 2024. DOI: 10.1097/INF.0000000000004291
dc.identifier.doi10.1097/INF.0000000000004291
dc.identifier.essn1532-0987
dc.identifier.issn0891-3668
dc.identifier.officialurlhttp://doi.org/10.1097/INF.0000000000004291
dc.identifier.pmid38421196
dc.identifier.urihttps://hdl.handle.net/20.500.14352/105286
dc.issue.number6
dc.journal.titleThe Pediatric Infectious Disease Journal
dc.language.isoeng
dc.page.final535
dc.page.initial532
dc.publisherWolters Kluwer Health
dc.relation.projectIDinfo:eu-repo/grantAgreement/ISCIII/COV20/01046
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//RD16%2F0022%2F0003/ES/RED DE SALUD MATERNO-INFANTIL Y DEL DESARROLLO/
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu613.2
dc.subject.cdu613.287.1
dc.subject.keywordCOVID-19
dc.subject.keywordHuman milk
dc.subject.keywordBreastfeeding
dc.subject.keywordAntibody
dc.subject.keywordNeutralization
dc.subject.ucmDietética y nutrición (Medicina)
dc.subject.ucmEnfermedades infecciosas
dc.subject.unesco3206 Ciencias de la Nutrición
dc.titleSpecific IgA, But Not IgG, in Human Milk From COVID-19-Infected Mothers Neutralizes SARS-CoV-2
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number43
dspace.entity.typePublication
relation.isAuthorOfPublication5a0ccdac-6fa4-40c7-8e77-082364812226
relation.isAuthorOfPublication.latestForDiscovery5a0ccdac-6fa4-40c7-8e77-082364812226

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