β-Lactam resistance in Haemophilus parasuis is mediated by plasmid pB1000 bearing blaROB-1
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2007
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American Society for Microbiology
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San Millan, A., Escudero, J. A., Catalan, A., Nieto, S., Farelo, F., Gibert, M., Moreno, M. A., Dominguez, L., & Gonzalez-Zorn, B. (2007). Beta-lactam resistance in Haemophilus parasuis Is mediated by plasmid pB1000 bearing blaROB-1. Antimicrobial agents and chemotherapy, 51(6), 2260–2264. https://doi.org/10.1128/AAC.00242-07
Abstract
beta-Lactam resistance in Haemophilus parasuis is an emerging phenomenon that has not yet been characterized from a molecular perspective. Clinical high-level beta-lactam-resistant isolates from Spain bore a novel plasmid, pB1000, expressing a functionally active ROB-1 beta-lactamase. Pulsed-field gel electrophoresis was applied for the first time to H. parasuis and showed that beta-lactam resistance is due to clonal spread of a resistant strain, BB1018, bearing pB1000.