Desarrollo de la reacción de Povarov aza-viníloga : aplicación a la síntesis de nuevos ligandos multidiana con actividad neuroprotectora
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2022
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25/02/2022
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Universidad Complutense de Madrid
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Abstract
Las enfermedades neurodegenerativas, debido a su carácter inequívocamente asociado a la edad, se están convirtiendo en uno de los problemas más acuciantes para los sistemas públicos de salud a medida que las sociedades actuales envejecen. Los enigmas que aún rodean al funcionamiento del sistema nervioso central, unidos a la compleja etiología multifactorial que está detrás de estas patologías, han provocado que el diagnóstico de estas enfermedades sea demasiado tardío, mientras que los tratamientos disponibles se limitan a un efecto paliativo sin ser capaces de actuar sobre las causas verdaderas del proceso patológico. Es por ello esencial que el incipiente conocimiento sobre los verdaderos orígenes de la neurodegeneración sea trasladado al diseño de fármacos orientados hacia esas nuevas dianas, así como deben ensayarse nuevas estrategias terapéuticas más adecuadas para el tratamiento de enfermedades de etiología multifactorial, como podría ser el empleo de fármacos multidiana...
Neurodegenerative diseases, which have a strong connection with aging, are becoming one of the most important challenges for national health services, as societies are getting older. We are still far from fully understanding the details of the way in which central nervous system works and furthermore neurodegenerative diseases have a complex multifactorial origin, and so their diagnosis often comes too late to reverse the pathological process. Available drugs are only useful to relieve symptoms, since they do not target the real origin of the neurodegeneration. In this context, it is necessary to apply the current knowledge about the onset of neurodegeneration to the design of drugs directed to emerging targets, and to consider new therapeutic strategies able to better deal with this kind of diseases, such as the use of multitarget directed ligands...
Neurodegenerative diseases, which have a strong connection with aging, are becoming one of the most important challenges for national health services, as societies are getting older. We are still far from fully understanding the details of the way in which central nervous system works and furthermore neurodegenerative diseases have a complex multifactorial origin, and so their diagnosis often comes too late to reverse the pathological process. Available drugs are only useful to relieve symptoms, since they do not target the real origin of the neurodegeneration. In this context, it is necessary to apply the current knowledge about the onset of neurodegeneration to the design of drugs directed to emerging targets, and to consider new therapeutic strategies able to better deal with this kind of diseases, such as the use of multitarget directed ligands...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Farmacia, leída el 25-02-2022