Publication:
Could Duodenal Molecular Mechanisms be Involved in the Hypocholesterolemic Effect of Silicon Used as Functional Ingredient in Late‐Stage Type 2 Diabetes Mellitus?

dc.contributor.authorHernández Martín, Marina
dc.contributor.authorBocanegra De Juana, Aránzazu
dc.contributor.authorRedondo Castillejo, Rocío
dc.contributor.authorMacho González, Adrián
dc.contributor.authorSánchez Muniz, Francisco José
dc.contributor.authorBenedí González, Juana María
dc.contributor.authorBastida Codina, Sara
dc.contributor.authorGarcía Fernández, Rosa Ana
dc.contributor.authorGarcimartín Álvarez, Alba
dc.contributor.authorLópez Oliva, M. Elvira
dc.date.accessioned2023-06-22T12:28:00Z
dc.date.available2023-06-22T12:28:00Z
dc.date.issued2022-10-10
dc.descriptionCRUE-CSIC (Acuerdos Transformativos 2022)
dc.description.abstractScope: Hypercholesterolemia increases the risk of mortality in type 2 diabetesmellitus (T2DM), especially in the late-stage. Consumption of bioactivecompounds as functional ingredients would help achieve therapeutic goals forcholesterolemia. Silicon has demonstrated a hypocholesterolemic effect andthe ability to reduce fat digestion. However, it is unclear whether silicon exertssuch effect in late-stage T2DM (LD) and the intestinal mechanisms involved.Methods and results: Three groups of eight rats were included: early-stageT2DM control (ED), LD, and the LD group treated with silicon (LD-Si) oncethe rats were diabetic. Morphological alterations of the duodenal mucosa, andlevels of markers involve in cholesterol absorption and excretion, besidecholesterolemia, and fecal excretion were assayed. Silicon included as afunctional ingredient significantly reduces cholesterolemia in part due to: 1)reducing cholesterol intestinal absorption by decreasing the absorptive areaand Acetyl-Coenzyme A acetyltransferase-2 (ACAT2) levels; and 2) increasingcholesterol excretion to the lumen by induction of the liver X receptor (LXR)and consequent increase of adenosine triphosphate-binding cassettetransporter (ABCG5/8).Conclusions: These results provide insight into the intestinal molecularmechanisms by which silicon reduces cholesterolemia and highlights theefficacy of the consumption of silicon-enriched functional foods in late-stageT2DM.
dc.description.departmentDepto. de Farmacología, Farmacognosia y Botánica
dc.description.departmentSección Deptal. de Fisiología (Farmacia)
dc.description.departmentDepto. de Medicina y Cirugía Animal
dc.description.facultyFac. de Farmacia
dc.description.facultyFac. de Veterinaria
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Ciencia e Innovación (MICINN)
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/75370
dc.identifier.doi10.1002/mnfr.202200104
dc.identifier.issn1613-4125
dc.identifier.officialurlhttps://doi.org/10.1002/mnfr.202200104
dc.identifier.urihttps://hdl.handle.net/20.500.14352/72579
dc.journal.titleMolecular Nutrition & Food Research
dc.language.isoeng
dc.page.initial2200104
dc.publisherWiley
dc.relation.projectIDPID2019-103872RB-I00 and /AEI/10.13039/501 100 011 033
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subject.cdu615.01/.03
dc.subject.keywordDuodenal absorptive area
dc.subject.keywordFunctional food
dc.subject.keywordLipid transporters hypercholesterolemia
dc.subject.keywordSilicon
dc.subject.keywordType 2 diabetes mellitus
dc.subject.ucmFarmacología (Farmacia)
dc.subject.unesco3209 Farmacología
dc.titleCould Duodenal Molecular Mechanisms be Involved in the Hypocholesterolemic Effect of Silicon Used as Functional Ingredient in Late‐Stage Type 2 Diabetes Mellitus?
dc.typejournal article
dspace.entity.typePublication
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