An Early Mediterranean-Based Nutritional Intervention during Pregnancy Reduces Metabolic Syndrome and Glucose Dysregulation Rates at 3 Years Postpartum

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dc.contributor.authorMelero, Verónica
dc.contributor.authorArnoriaga, Maria
dc.contributor.authorBarabash Bustelo, Ana
dc.contributor.authorValerio, Johanna
dc.contributor.authordel Valle, Laura
dc.contributor.authorMartín O'Connor, Rocío
dc.contributor.authorDe Miguel Novoa, María De La Paz
dc.contributor.authorDíaz Pérez, José Ángel
dc.contributor.authorFamiliar, Cristina
dc.contributor.authorMoraga, Inmaculada
dc.contributor.authorDurán Rodríguez-Hervada, Alejandra
dc.contributor.authorCuesta, Martín
dc.contributor.authorTorrejón, María José
dc.contributor.authorMartínez Novillo, Mercedes
dc.contributor.authorMoreno, María
dc.contributor.authorRomera, Gisela
dc.contributor.authorRunkle De La Vega, Isabel Ana
dc.contributor.authorPazos, Mario
dc.contributor.authorRubio Herrera, Miguel Ángel
dc.contributor.authorMatía Martín, María Del Pilar
dc.contributor.authorCalle Pascual, Alfonso Luis
dc.date.accessioned2024-05-14T07:51:09Z
dc.date.available2024-05-14T07:51:09Z
dc.date.issued2023-07-22
dc.description2023 Descuento MDPI
dc.description.abstractA Mediterranean diet (MedDiet)-based intervention reduces the rate of immediate postpartum maternal metabolic disorders. Whether these effects persist long-term remains to be determined. A total of 2526 normoglycemic women were randomized before the 12th gestational week (GW). IG women followed a MedDiet with extra virgin olive oil (EVOO) (>40 mL/day) and a handful of nuts daily, whereas CG women had to restrict all kinds of dietary fat. At 3 months postpartum, a motivational lifestyle interview was held. The endpoint of the study evaluated the rate of abnormal glucose regulation (AGR) and metabolic syndrome (MetS) at 3 years postpartum in women of the San Carlos cohort. A total of 369/625 (59%) CG women and 1031/1603 (64.3%) IG women were finally analyzed. At 3 months and 3 years postdelivery, the IG women showed higher adherence to the MedDiet, which was associated with lower values of body mass index (BMI) and lipid and glycemic profiles. Body weight change and waist circumference were lower in the IG women. After applying multiple regression analysis, the ORs (95%CI) resulted in AGR (3.18 (2.48–4.08); p < 0.001)/MetS (3.79 (1.81–7.95); p = 0.001) for women with GDM and higher OR for development of MetS in CG women (3.73 (1.77–7.87); p = 0.001). A MedDiet-based intervention early in pregnancy demonstrated persistent beneficial effects on AGR and MetS rates at 3 years postpartum.
dc.description.departmentDepto. de Medicina
dc.description.facultyFac. de Medicina
dc.description.fundingtypeDescuento UCM
dc.description.refereedTRUE
dc.description.sponsorshipInstituto de Salud Carlos III
dc.description.sponsorshipMinisterio de Ciencia, Innovación y Universidades (España)
dc.description.sponsorshipEuropean Commission
dc.description.statuspub
dc.identifier.citationMelero, V., Arnoriaga, M., Barabash, A., Valerio, J., Del Valle, L., Martin O'Connor, R., de Miguel, M. P., Diaz, J. A., Familiar, C., Moraga, I., Duran, A., Cuesta, M., Torrejon, M. J., Martinez-Novillo, M., Moreno, M., Romera, G., Runkle, I., Pazos, M., Rubio, M. A., Matia-Martín, P., … Calle-Pascual, A. L. (2023). An Early Mediterranean-Based Nutritional Intervention during Pregnancy Reduces Metabolic Syndrome and Glucose Dysregulation Rates at 3 Years Postpartum. Nutrients, 15(14), 3252. https://doi.org/10.3390/nu15143252
dc.identifier.doi10.3390/nu15143252
dc.identifier.essn2072-6643
dc.identifier.officialurlhttps://doi.org/10.3390/nu15143252
dc.identifier.pmid37513670
dc.identifier.urihttps://hdl.handle.net/20.500.14352/103977
dc.issue.number3252
dc.journal.titleNutrients
dc.language.isoeng
dc.page.final13
dc.page.initial1
dc.publisherMDPI
dc.relation.projectIDinfo:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI20%2F01758/ES/INTERACCION GENOTIPO-DIETA EN EL DESARROLLO DE DIABETES MELLITUS GESTACIONAL Y SUBSECUENTE RIESGO CARDIOMETABOLICO./
dc.relation.projectIDRTC2019-007406-1
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu613.2:618.2
dc.subject.keywordAbnormal glucose regulation
dc.subject.keywordGestational diabetes mellitus
dc.subject.keywordNutritional intervention
dc.subject.keywordMediterranean diet
dc.subject.keywordPostpartum
dc.subject.keywordCardiovascular disease
dc.subject.keywordMetabolic syndrome
dc.subject.ucmGinecología y obstetricia
dc.subject.ucmDietética y nutrición (Medicina)
dc.subject.unesco3201.08 Ginecología
dc.subject.unesco3206 Ciencias de la Nutrición
dc.titleAn Early Mediterranean-Based Nutritional Intervention during Pregnancy Reduces Metabolic Syndrome and Glucose Dysregulation Rates at 3 Years Postpartum
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number15(14)
dspace.entity.typePublication
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