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TUP1-mediated filamentation in Candida albicans leads to inability to colonize the mouse gut.

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dc.contributor.authorRomán González, Elvira
dc.contributor.authorHuertas, Blanca
dc.contributor.authorPrieto, Daniel
dc.contributor.authorDíez Orejas, Rosalía María
dc.contributor.authorPla Alonso, Jesús
dc.date.accessioned2023-06-17T13:23:56Z
dc.date.available2023-06-17T13:23:56Z
dc.date.issued2018-06-01
dc.description.abstractAIM To investigate the role of Candida albicans TUP1-mediated filamentation in the colonization of the mice gut. MATERIALS & METHODS We used molecular genetics to generate a strain where filamentation is regulated by altering the expression of the TUP1 gene with tetracyclines. RESULTS The colonization rates reached with the TUP1-RFP strain were lower compared with wild-type strain and completely absent after induction of filamentation. No differences in the susceptibility to bile salts nor in the adhesion to the mouse intestine epithelium were observed. CONCLUSION Blockage of C. albicans in a filamentous form impedes gut cell colonization in the mouse.en
dc.description.departmentDepto. de Microbiología y Parasitología
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Economía, Comercio y Empresa (España)
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/55649
dc.identifier.citationRomán González, E., Huertas, B., Prieto, D. et al. «TUP1 -Mediated Filamentation in Candida Albicans Leads to Inability to Colonize the Mouse Gut». Future Microbiology, vol. 13, n.o 8, junio de 2018, pp. 857-67. DOI.org (Crossref), https://doi.org/10.2217/fmb-2018-0012.
dc.identifier.doi10.2217/fmb-2018-0012
dc.identifier.issn1746-0921
dc.identifier.officialurlhttps//doi.org/10.2217/fmb-2018-0012
dc.identifier.relatedurlhttps://www.futuremedicine.com/
dc.identifier.urihttps://hdl.handle.net/20.500.14352/13365
dc.journal.titleFuture microbiology
dc.language.isoeng
dc.page.final867
dc.page.initial857
dc.publisherFuture Medicine
dc.relation.projectIDBIO2015–6477 (MINECO)
dc.rights.accessRightsopen access
dc.subject.cdu579
dc.subject.keywordCandida albicans
dc.subject.keywordCommensalism
dc.subject.keywordFilamentous growth
dc.subject.keywordTUP1
dc.subject.ucmMicrobiología (Farmacia)
dc.subject.unesco3302.03 Microbiología Industrial
dc.titleTUP1-mediated filamentation in Candida albicans leads to inability to colonize the mouse gut.en
dc.typejournal article
dc.volume.number13
dspace.entity.typePublication
relation.isAuthorOfPublicationb49786d6-3a86-4ebe-a063-1168c176593a
relation.isAuthorOfPublicatione9388a5d-dfe6-4703-a755-5e10fc0dc5ff
relation.isAuthorOfPublication9b1cdd2c-128a-4281-9dd9-8a64d882b306
relation.isAuthorOfPublication.latestForDiscoveryb49786d6-3a86-4ebe-a063-1168c176593a

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