TUP1-mediated filamentation in Candida albicans leads to inability to colonize the mouse gut.
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2018
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Future Medicine
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Román González, E., Huertas, B., Prieto, D. et al. «TUP1 -Mediated Filamentation in Candida Albicans Leads to Inability to Colonize the Mouse Gut». Future Microbiology, vol. 13, n.o 8, junio de 2018, pp. 857-67. DOI.org (Crossref), https://doi.org/10.2217/fmb-2018-0012.
Abstract
AIM
To investigate the role of Candida albicans TUP1-mediated filamentation in the colonization of the mice gut.
MATERIALS & METHODS
We used molecular genetics to generate a strain where filamentation is regulated by altering the expression of the TUP1 gene with tetracyclines.
RESULTS
The colonization rates reached with the TUP1-RFP strain were lower compared with wild-type strain and completely absent after induction of filamentation. No differences in the susceptibility to bile salts nor in the adhesion to the mouse intestine epithelium were observed.
CONCLUSION
Blockage of C. albicans in a filamentous form impedes gut cell colonization in the mouse.