New circulating biomarkers for predicting cardiovascular death in healthy population

Olle, Melander; Modrego, Javier; Zamorano León, José Javier; Santos Sancho, Juana María; Lahera Julia, Vicente; López Farre, Antonio José

New circulating biomarkers for predicting cardiovascular death in healthy population

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Official URL

https://onlinelibrary.wiley.com/doi/10.1111/jcmm.12652

Publication date

2015

Authors

Olle, Melander

Modrego, Javier

Zamorano León, José Javier

Santos Sancho, Juana María

Lahera Julia, Vicente

López Farre, Antonio José

Publisher

Wiley Open Access

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URI

https://hdl.handle.net/20.500.14352/100649

Citation

Melander O, Modrego J, Zamorano-León JJ, Santos-Sancho JM, Lahera V, López-Farré AJ. New circulating biomarkers for predicting cardiovascular death in healthy population. J Cell Mol Med. 2015 Oct;19(10):2489-99. doi: 10.1111/jcmm.12652

Abstract

There is interest to analyse newer biomarkers to identify healthy individuals at risk to develop cardiovascular disease (CVD) incidents and death. To determine in healthy individuals new circulating protein biomarkers, whose systemic levels may be associated with the risk of future development of CVD incidents and death. The study was performed in 82 individuals from the Malm€o Diet and Cancer study cohort, free from CVD of whom 41 developed CVD and 41 did not. Plasma proteins related to inflammation and thrombo-coagulating processes were analysed. a1-antitrypsin isotype 3 plasma levels were significantly higher while apolipoprotein J plasma levels were lower in participants that developed CVD incidents than those that did not develop acute cardiovascular episode. Of 82 participants, 17 died by CVD causes. There were proteins whose expression in plasma was significantly higher in participants suffering CVD death as compared with those that did not die by CVD. These proteins included: fibrinogen b-chain isotypes 1 and 3, fibrinogen-c-chain isotype 2, vitamin D-binding protein isotypes 1, 2 and 3, a1-antitrypsin isotypes 3 and 6, haptoglobin isotypes 3,4,5 and 5, haemopexin isotypes 1 and 2, and Rho/Rac guanine nucleotide exchange factor 2. Moreover, apolipoprotein J plasma levels were found lower in participants that died by cardiovascular cause. Association between plasma levels of proteins and CVD death was independent of age, gender, conventional risk factors and plasma C-reactive protein levels. Several protein plasma levels and protein isotypes related to inflammation and thrombo-coagulating phenomena were independently associated with the risk of future CVD death.