Supercritical fluid impregnation of naproxen into mesoporous SiO2 SBA-15

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dc.contributor.authorGonzález, Juan
dc.contributor.authorPérez Velilla, Eduardo
dc.contributor.authorPepczynska, Marzena
dc.contributor.authorCalvo Garrido, María Lourdes
dc.contributor.authorCabañas Poveda, Albertina
dc.date.accessioned2024-01-09T15:05:17Z
dc.date.available2024-01-09T15:05:17Z
dc.date.issued2023
dc.description.abstractNaproxen was impregnated into mesoporous SiO2 SBA-15 using the Supercritical Solution Impregnation (SSI) technique. Experiments were performed at 50–70ºC and 15–25 MPa in pure CO2 and CO2 modified with ethanol, ethyl acetate and menthol. Materials were also impregnated from liquid solutions in ethanol and chloroform. In the SSI experiments, naproxen was deposited on the internal surface of the mesopores as shown by N2-adsorption experiments. The percentage of naproxen impregnated decreased from 11.1% to 7.4% mass as the CO2 density increased. Likewise, adding ethanol, ethyl acetate or menthol to CO2 decreased the percentage of naproxen adsorbed on the support. Thermal analysis showed that naproxen impregnated on SiO2 by SSI became amorphous. FTIR and XRD confirmed the loss of crystallinity of naproxen and its interaction with the SiO2 support. Samples impregnated in liquid medium however kept partially their crystallinity. Release tests of naproxen on SiO2 SBA-15 prepared by SSI followed an almost zero-order release profile; the drug is released at a constant rate into a PBS pH= 7.4 medium. The release rate slowed down in comparison to that of pure naproxen, due to the interaction of the drug with the support and the diffusion of the drug outside the support mesopores. Thus, a sustained release system was achieved, which may help to attain a longer therapeutic effect with a lower naproxen dose.
dc.description.departmentDepto. de Química Física
dc.description.facultyFac. de Ciencias Químicas
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Ciencia e Innovación (España)
dc.description.statuspub
dc.identifier.citationJuan González, Eduardo Pérez, Marzena Pepczynska, Lourdes Calvo, Albertina Cabañas, Supercritical Solution Impregnation of naproxen into mesoporous SiO2 SBA-15, Journal of CO2 Utilization, Volume 73, 2023, 102518. https://doi.org/10.1016/j.jcou.2023.102518.
dc.identifier.doi10.1016/j.jcou.2023.102518
dc.identifier.issn2212-9839
dc.identifier.officialurlhttps://doi.org/10.1016/j.jcou.2023.102518
dc.identifier.urihttps://hdl.handle.net/20.500.14352/92071
dc.journal.titleJournal of CO2 utilization
dc.language.isoeng
dc.page.initial102518
dc.publisherElsevier
dc.relation.projectIDRTI2018-097230-B-100
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu544
dc.subject.keywordSupercritical CO2; Drug delivery; Sustained release; Drug amorphization; Supercritical Solution Impregnation (SSI); Supercritical Solvent Impregnation
dc.subject.ucmQuímica física (Química)
dc.subject.ucmMateriales
dc.subject.ucmFarmacología (Farmacia)
dc.subject.ucmIngeniería química
dc.subject.unesco23 Química
dc.subject.unesco2210 Química Física
dc.subject.unesco3209 Farmacología
dc.titleSupercritical fluid impregnation of naproxen into mesoporous SiO2 SBA-15
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number73
dspace.entity.typePublication
relation.isAuthorOfPublication3dbefa95-edab-433b-951f-82e8bea056e1
relation.isAuthorOfPublicationf2587cb3-725d-4333-90ba-d4aac12ec04c
relation.isAuthorOfPublication08f9e67b-e7ba-420b-a651-37a03ba04f0c
relation.isAuthorOfPublication.latestForDiscovery08f9e67b-e7ba-420b-a651-37a03ba04f0c
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