Oxidative and Molecular-Structural Alterations of Spermatozoa in Swine and Ram Exposed to the Triazole Ipconazole

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dc.contributor.authorFalero, Cristian
dc.contributor.authorHuanca, Wilfredo
dc.contributor.authorBarrios Arpi, Luis
dc.contributor.authorLira Mejía, Boris
dc.contributor.authorRamos-Coaguila, Olger
dc.contributor.authorTorres, Edith
dc.contributor.authorRamos Alonso, Eva
dc.contributor.authorRomero Martínez, Manuel Alejandro
dc.contributor.authorRamos Gonzalez, Mariella
dc.date.accessioned2025-04-29T15:43:29Z
dc.date.available2025-04-29T15:43:29Z
dc.date.issued2025
dc.descriptionAuthor Contributions: Conceptualization, W.H., E.T. and M.R.-G.; Data curation, L.B.-A.; Formal analysis, B.L.-M., A.R. and and E.R.; Funding acquisition, M.R.-G.; Investigation, C.F., B.L.-M., L.B.-A., O.R.-C., E.T. and M.R.-G.; Methodology, C.F., O.R.-C., E.T. and A.R.; Project administration, M.R.-G.; Resources, W.H., B.L.-M. and O.R.-C.; Software, A.R.; Validation, M.R.-G.; Visualization, W.H., L.B.-A.
dc.description.abstractTriazole pesticides are widely used throughout the world, but their abuse causes toxic effects in non-targeted organisms. In the present study, the cytotoxic effect of the triazole ipconazole was evaluated in porcine and ram spermatozoa. Ipconazole significantly reduced sperm viability, increased ROS levels, altered catalase and SOD enzyme activity, and caused alterations in the molecular mRNA expression of structural biomarkers (PRM1, ODF2, AKAP4, THEG, SPACA3 and CLGN) related to fertility in males, as well as the overexpression of BAX (cell death) and ROMO1 (oxidative stress) mRNA. Our results indicate that the fungicide triazole is involved in cellular, enzymatic and molecular alteration of porcine and ram spermatozoa, and is possibly a factor in the development of infertility in male mammals
dc.description.departmentDepto. de Farmacología y Toxicología
dc.description.facultyFac. de Veterinaria
dc.description.refereedTRUE
dc.description.sponsorshipNational University of San Marcos (Italia)
dc.description.statuspub
dc.identifier.citationFalero, C., Huanca, W., Barrios-Arpi, L., Lira-Mejía, B., Ramos-Coaguila, O., Torres, E., Ramos, E., Romero, A., & Ramos-Gonzalez, M. (2025). Oxidative and Molecular-Structural Alterations of Spermatozoa in Swine and Ram Exposed to the Triazole Ipconazole. Toxics, 13(3), 176. https://doi.org/10.3390/toxics13030176
dc.identifier.doi10.3390/toxics13030176
dc.identifier.essn2305-6304
dc.identifier.officialurlhttps://doi.org/10.3390/toxics13030176
dc.identifier.pmid40137503
dc.identifier.urihttps://hdl.handle.net/20.500.14352/119760
dc.issue.number3
dc.journal.titleToxics
dc.language.isoeng
dc.page.final13
dc.page.initial1
dc.publisherMDPI
dc.relation.projectIDPCONFIGI-A24080071
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu579.62
dc.subject.keywordIpconazole
dc.subject.keywordOxidative stress
dc.subject.keywordSpermiotoxicity
dc.subject.keywordStructural biomarkers
dc.subject.ucmMicrobiología (Veterinaria)
dc.subject.unesco3109.05 Microbiología
dc.titleOxidative and Molecular-Structural Alterations of Spermatozoa in Swine and Ram Exposed to the Triazole Ipconazole
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number13
dspace.entity.typePublication
relation.isAuthorOfPublication5f16335c-a2b9-4244-b00f-215f16e7150c
relation.isAuthorOfPublicationc658be58-bda9-4100-ad65-bac31e1256af
relation.isAuthorOfPublication.latestForDiscovery5f16335c-a2b9-4244-b00f-215f16e7150c

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