Monitoring Breathing Rate at Home Allows Early Identification of COPD Exacerbations
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Publication date
2012
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Publisher
Elsevier
Citation
Yañez AM, Guerrero D, Pérez de Alejo R, Garcia-Rio F, Alvarez-Sala JL, Calle-Rubio M, de Molina RM, Valle Falcones M, Ussetti P, Sauleda J, García EZ, Rodríguez-González-Moro JM, Franco Gay M, Torrent M, Agustí A. Monitoring breathing rate at home allows early identification of COPD exacerbations. Chest. 2012 Dec;142(6):1524-1529. doi: 10.1378/chest.11-2728. PMID: 22797131.
Abstract
Background
Respiratory frequency increases during exacerbations of COPD (ECOPD). We hypothesized that this increase can be detected at home before ECOPD hospitalization.
Methods
To test this hypothesis, respiratory frequency was monitored at home daily for 3 months in 89 patients with COPD (FEV1, 42.3% ± 14.0%; reference) who were receiving domiciliary oxygen therapy (9.6 ± 4.0 h/d).
Results
During follow-up, 30 patients (33.7%) required hospitalization because of ECOPD. In 21 of them (70%), mean respiratory frequency increased (vs baseline) during the 5 days that preceded it (from 15.2 ± 4.3/min to 19.1 ± 5.9/min, P < .05). This was not the case in patients without ECOPD (16.1 ± 4.8/min vs 15.9 ± 4.9/min). Receiver operating characteristic analysis showed that 24 h before hospitalization, a mean increase of 4.4/min (30% from baseline) provided the best combination of sensitivity (66%) and specificity (93%) (area under the curve [AUC] = 0.79, P < .05). Two days before hospitalization, a mean increase of 2.3/min (15% change from baseline) was associated with a sensitivity of 72% and a specificity of 77% (AUC = 0.76, P < .05).
Conclusions
Respiratory frequency can be monitored daily at home in patients with COPD receiving domiciliary oxygen therapy. In these patients, breathing rate increases significantly days before they require hospitalization because of ECOPD. This may offer a window of opportunity for early intervention.