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Carbosilane dendrimers as carriers of siRNA

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dc.contributor.authorJiménez, José Luis
dc.contributor.authorGómez, Rafael
dc.contributor.authorBriz, Veronica
dc.contributor.authorMadrid González, Ricardo
dc.contributor.authorBryszewsk, Maria
dc.contributor.authorMata, Francisco .Javier. de la
dc.contributor.authorMuñoz-Fernández, María Ángeles
dc.date.accessioned2024-02-06T16:01:44Z
dc.date.available2024-02-06T16:01:44Z
dc.date.issued2012
dc.descriptionAcknowledgements Sources of financial support: Grants from MNT-ERA NET transnational call 2007; COST Action (TD0802), Red RIS RD06-0006-0035, Fondo de Investigación Sanitaria (PI09/02029; PI080222; PI081495), Fundación para la Investigación y la Prevención del SIDA en España (FIPSE 240800/09), EuroEraNet DENPEPTHIV PS09/02669, DENANORNA, and CIBER-BBN del Instituto de Salud Carlos III. JLJF is supported by Programa de Investigación de la Consejería de Sanidad de la Comunidad de Madrid.
dc.description.abstractDespite the enormous possibilities of RNAi, there still exist many problems that need to be addressed. Obstacles in delivery, target cell transfection, stability/degradation, transient activity, secondary effects, toxicity caused by the delivery vector, and resistance all hinder the path of carrying out in vivo experiments with RNAi and further developing RNAi as a new therapy for clinical use. Notwithstanding, the majority of research that uses RNAi depends on a delivery vector of some kind. This review offers a brief overview of the current status of carbosilane dendrimers as siRNA delivery vectors.
dc.description.departmentDepto. de Genética, Fisiología y Microbiología
dc.description.facultyFac. de Ciencias Biológicas
dc.description.refereedTRUE
dc.description.sponsorshipFundación para la Investigación y la Prevención del SIDA en España
dc.description.sponsorshipInstituto de Salud Carlos III
dc.description.sponsorshipComunidad de Madrid
dc.description.statuspub
dc.identifier.citationJiménez, J. L., et al. «Carbosilane Dendrimers as Carriers of siRNA». Journal of Drug Delivery Science and Technology, vol. 22, n.o 1, 2012, pp. 75-82. https://doi.org/10.1016/S1773-2247(12)50007-9.
dc.identifier.doi10.1016/s1773-2247(12)50007-9
dc.identifier.essn2588-8943
dc.identifier.issn1773-2247
dc.identifier.officialurlhttps://doi.org/10.1016/S1773-2247(12)50007-9
dc.identifier.urihttps://hdl.handle.net/20.500.14352/99626
dc.issue.number1
dc.journal.titleJournal of Drug Delivery Science and Technology
dc.language.isoeng
dc.page.final82
dc.page.initial75
dc.publisherElsevier
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsrestricted access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu575
dc.subject.keywordRNAi
dc.subject.keywordCarbosilane dendrimers
dc.subject.keywordDendrimers
dc.subject.keywordNon-viral vectors
dc.subject.keywordHIV infection
dc.subject.ucmGenética
dc.subject.unesco2409 Genética
dc.titleCarbosilane dendrimers as carriers of siRNA
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number22
dspace.entity.typePublication
relation.isAuthorOfPublication38610649-8d87-431b-8b40-b51ae401b990
relation.isAuthorOfPublication.latestForDiscovery38610649-8d87-431b-8b40-b51ae401b990

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