Carbosilane dendrimers as carriers of siRNA
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2012
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Elsevier
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Jiménez, J. L., et al. «Carbosilane Dendrimers as Carriers of siRNA». Journal of Drug Delivery Science and Technology, vol. 22, n.o 1, 2012, pp. 75-82. https://doi.org/10.1016/S1773-2247(12)50007-9.
Abstract
Despite the enormous possibilities of RNAi, there still exist many problems that need to be addressed. Obstacles in delivery, target cell transfection, stability/degradation, transient activity, secondary effects, toxicity caused by the delivery vector, and resistance all hinder the path of carrying out in vivo experiments with RNAi and further developing RNAi as a new therapy for clinical use. Notwithstanding, the majority of research that uses RNAi depends on a delivery vector of some kind. This review offers a brief overview of the current status of carbosilane dendrimers as siRNA delivery vectors.
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Acknowledgements
Sources of financial support: Grants from MNT-ERA NET transnational call 2007; COST Action (TD0802), Red RIS RD06-0006-0035, Fondo de Investigación Sanitaria (PI09/02029; PI080222; PI081495), Fundación para la Investigación y la Prevención del SIDA en España (FIPSE 240800/09), EuroEraNet DENPEPTHIV PS09/02669, DENANORNA, and CIBER-BBN del Instituto de Salud Carlos III. JLJF is supported by Programa de Investigación de la Consejería de Sanidad de la Comunidad de Madrid.