A 3D Peptide/[60]Fullerene hybrid for multivalent recognition

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dc.contributor.authorGallego, Iván
dc.contributor.authorRamos‐Soriano, Javier
dc.contributor.authorMéndez‐Ardoy, Alejandro
dc.contributor.authorCabrera González, Justo Enrique
dc.contributor.authorLostalé‐Seijo, Irene
dc.contributor.authorIllescas Martínez, Beatriz María
dc.contributor.authorMartín León, Nazario
dc.contributor.authorReina, Jose
dc.contributor.authorMontenegro, Javier
dc.date.accessioned2024-01-12T11:10:42Z
dc.date.available2024-01-12T11:10:42Z
dc.date.issued2022
dc.description.abstractFully substituted peptide/[60]fullerene hexakis‐adducts offer an excellent opportunity for multivalent protein recognition. In contrast to monofunctionalized fullerene hybrids, peptide/[60]fullerene hexakis‐adducts display multiple copies of a peptide in close spatial proximity and in the three dimensions of space. High affinity peptide binders for almost any target can be currently identified by in vitro evolution techniques, often providing synthetically simpler alternatives to natural ligands. However, despite the potential of peptide/[60]fullerene hexakis‐adducts, these promising conjugates have not been reported to date. Here we present a synthetic strategy for the construction of 3D multivalent hybrids that are able to bind with high affinity the E‐selectin. The here synthesized fully substituted peptide/[60]fullerene hybrids and their multivalent recognition of natural receptors constitute a proof of principle for their future application as functional biocompatible materials.en
dc.description.departmentDepto. de Química Orgánica
dc.description.facultyFac. de Ciencias Químicas
dc.description.refereedTRUE
dc.description.sponsorshipXunta de Galicia
dc.description.sponsorshipEuropean Commission
dc.description.sponsorshipMinisterio de Ciencia e Innovación (España)
dc.description.statuspub
dc.identifier.citationGallego, Iván, et al. «A 3D Peptide/[60]Fullerene Hybrid for Multivalent Recognition». Angewandte Chemie International Edition, vol. 61, n.o 41, octubre de 2022, p. e202210043. https://doi.org/10.1002/anie.202210043.
dc.identifier.doi10.1002/ange.202210043
dc.identifier.essn1521-3773
dc.identifier.issn0044-8249
dc.identifier.officialurlhttps://doi.org/10.1002/anie.202210043
dc.identifier.urihttps://hdl.handle.net/20.500.14352/92739
dc.issue.number41
dc.journal.titleAngewandte Chemie International Edition
dc.language.isoeng
dc.publisherWiley
dc.rights.accessRightsopen access
dc.subject.cdu547
dc.subject.keywordFullerenes
dc.subject.keywordGlycomimetic
dc.subject.keywordLectin
dc.subject.keywordMultivalency
dc.subject.keywordPeptides
dc.subject.ucmQuímica orgánica (Química)
dc.subject.unesco2306 Química Orgánica
dc.subject.unesco23 Química
dc.titleA 3D Peptide/[60]Fullerene hybrid for multivalent recognition
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number61
dspace.entity.typePublication
relation.isAuthorOfPublication5fdca92d-6eb3-4245-bdfe-1bf73af9881b
relation.isAuthorOfPublication487572dc-86c7-4d3c-9d0d-a91df9023595
relation.isAuthorOfPublicationbbb2c026-daab-46a1-8b57-fa3cf1a7d41a
relation.isAuthorOfPublication.latestForDiscovery5fdca92d-6eb3-4245-bdfe-1bf73af9881b
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