A 3D Peptide/[60]Fullerene hybrid for multivalent recognition

Cabrera González, Justo Enrique; Illescas Martínez, Beatriz María; Martín León, Nazario; Gallego, Iván; Ramos‐Soriano, Javier; Méndez‐Ardoy, Alejandro; Irene Lostalé‐Seijo; Jose J. Reina; Javier Montenegro

A 3D Peptide/[60]Fullerene hybrid for multivalent recognition

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Angew Chem Int Ed - 2022 - Gallego - A 3D Peptide 60 Fullerene Hybrid for Multivalent Recognition.pdf (1.87 MB)

Publication date

2022

Publisher

Wiley

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URI

https://hdl.handle.net/20.500.14352/92739

Citation

Angew. Chem. Int. Ed. 2022, 61, e202210043

Abstract

Fully substituted peptide/[60]fullerene hexakis‐adducts offer an excellent opportunity for multivalent protein recognition. In contrast to monofunctionalized fullerene hybrids, peptide/[60]fullerene hexakis‐adducts display multiple copies of a peptide in close spatial proximity and in the three dimensions of space. High affinity peptide binders for almost any target can be currently identified by in vitro evolution techniques, often providing synthetically simpler alternatives to natural ligands. However, despite the potential of peptide/[60]fullerene hexakis‐adducts, these promising conjugates have not been reported to date. Here we present a synthetic strategy for the construction of 3D multivalent hybrids that are able to bind with high affinity the E‐selectin. The here synthesized fully substituted peptide/[60]fullerene hybrids and their multivalent recognition of natural receptors constitute a proof of principle for their future application as functional biocompatible materials.