Expression Analysis of hsa-miR-181a-5p, hsa-miR-143-3p, hsa-miR-132-3p and hsa-miR-23a-3p as Biomarkers in Colorectal Cancer—Relationship to the Body Mass Index

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dc.contributor.authorTesolato, Sofía
dc.contributor.authorGonzález-Gamo, Daniel
dc.contributor.authorBarabash Bustelo, Ana
dc.contributor.authorClaver, Paula
dc.contributor.authorDe La-Serna Esteban, Sofía Cristina
dc.contributor.authorDomínguez Serrano, María Inmaculada
dc.contributor.authorDziakova, Jana
dc.contributor.authorJuan Chocano, María Del Carmen De
dc.contributor.authorTorres García, Antonio José
dc.contributor.authorIniesta Serrano, María Pilar
dc.contributor.editorSterpetti, Antonio V.
dc.date.accessioned2023-12-20T13:08:00Z
dc.date.available2023-12-20T13:08:00Z
dc.date.issued2023-06-24
dc.description.abstractColorectal cancer (CRC) is one of the main tumor pathologies in our society considering its incidence and mortality. Various authors have linked the development of CRC with overweight and obesity. However, no molecular markers have been defined to connect both pathologies and that can be assessed in serum for diagnostic and/or prognostic purposes. The main objective of this work is to analyze and correlate the expression levels of four miRNAs previously associated with cancer and/or obesity in patients affected by CRC, as well as in a control group without cancer, considering the body mass index (BMI) of subjects. The main novelty of this study consists in the variety of samples investigated: adipose tissues, omental and subcutaneous; serum; and tumor and non-tumor tissues in the case of CRC patients. Results conclude about the utility mainly of hsa-miR-143-3p and hsa-miR-181a-5p in the clinical management of CRC.
dc.description.departmentDepto. de Bioquímica y Biología Molecular
dc.description.departmentDepto. de Medicina
dc.description.departmentDepto. de Cirugía
dc.description.facultyFac. de Farmacia
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.sponsorshipCarlos III Institute of Health (Ministerio de Economía y Competitividad), Spain
dc.description.sponsorshipEuropean Union through the European Regional Development Fund (ERDF) ‘A way to make Europe’
dc.description.statuspub
dc.identifier.citationTesolato, S.E.; González-Gamo, D.; Barabash, A.; Claver, P.; de la Serna, S.C.; Domínguez-Serrano, I.; Dziakova, J.; de Juan, C.; Torres, A.J.; Iniesta, P. Expression Analysis of hsa-miR-181a-5p, hsa-miR-143-3p, hsa-miR-132-3p and hsa-miR-23a-3p as Biomarkers in Colorectal Cancer—Relationship to the BodyMass Index. Cancers 2023, 15, 3324. https://doi.org/10.3390/ cancers15133324
dc.identifier.doi10.3390/cancers15133324
dc.identifier.issn2072-6694
dc.identifier.officialurlhttps://doi.org/10.3390/cancers15133324
dc.identifier.urihttps://hdl.handle.net/20.500.14352/91602
dc.issue.number3324
dc.journal.titleCancers
dc.language.isoeng
dc.publisherMDPI
dc.relation.projectIDinfo:eu-repo/grantAgreement/PI19/00073
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject.cdu577.2
dc.subject.cdu616.348-089
dc.subject.keywordColorectal Cancer
dc.subject.keywordAdipose tissue
dc.subject.keywordmiRNAs
dc.subject.keywordSerum biomarkers
dc.subject.keywordObesity
dc.subject.ucmBiología molecular (Farmacia)
dc.subject.ucmEndocrinología
dc.subject.ucmCirugía
dc.subject.ucmDietética y nutrición (Farmacia)
dc.subject.unesco24 Ciencias de la Vida
dc.subject.unesco2407 Biología celular
dc.titleExpression Analysis of hsa-miR-181a-5p, hsa-miR-143-3p, hsa-miR-132-3p and hsa-miR-23a-3p as Biomarkers in Colorectal Cancer—Relationship to the Body Mass Index
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number15
dspace.entity.typePublication
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