Expression Analysis of hsa-miR-181a-5p, hsa-miR-143-3p, hsa-miR-132-3p and hsa-miR-23a-3p as Biomarkers in Colorectal Cancer—Relationship to the Body Mass Index

Tesolato, Sofía; González-Gamo, Daniel; Barabash Bustelo, Ana; Claver, Paula; De La-Serna Esteban, Sofía Cristina; Domínguez Serrano, María Inmaculada; Dziakova, Jana; Juan Chocano, María Del Carmen De; Torres García, Antonio José; Iniesta Serrano, María Pilar

Expression Analysis of hsa-miR-181a-5p, hsa-miR-143-3p, hsa-miR-132-3p and hsa-miR-23a-3p as Biomarkers in Colorectal Cancer—Relationship to the Body Mass Index

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Official URL

https://doi.org/10.3390/cancers15133324

Publication date

2023

Editors

Sterpetti, Antonio V.

Publisher

MDPI

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URI

https://hdl.handle.net/20.500.14352/91602

Citation

Tesolato, S.E.; González-Gamo, D.; Barabash, A.; Claver, P.; de la Serna, S.C.; Domínguez-Serrano, I.; Dziakova, J.; de Juan, C.; Torres, A.J.; Iniesta, P. Expression Analysis of hsa-miR-181a-5p, hsa-miR-143-3p, hsa-miR-132-3p and hsa-miR-23a-3p as Biomarkers in Colorectal Cancer—Relationship to the BodyMass Index. Cancers 2023, 15, 3324. https://doi.org/10.3390/ cancers15133324

Abstract

Colorectal cancer (CRC) is one of the main tumor pathologies in our society considering its incidence and mortality. Various authors have linked the development of CRC with overweight and obesity. However, no molecular markers have been defined to connect both pathologies and that can be assessed in serum for diagnostic and/or prognostic purposes. The main objective of this work is to analyze and correlate the expression levels of four miRNAs previously associated with cancer and/or obesity in patients affected by CRC, as well as in a control group without cancer, considering the body mass index (BMI) of subjects. The main novelty of this study consists in the variety of samples investigated: adipose tissues, omental and subcutaneous; serum; and tumor and non-tumor tissues in the case of CRC patients. Results conclude about the utility mainly of hsa-miR-143-3p and hsa-miR-181a-5p in the clinical management of CRC.